Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LILRB1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10859
Official gene symbolLILRB1
Full nameleukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Aliases,CD85,CD85J,FLJ37515,ILT2,LIR-1,LIR1,MIR-7,MIR7,
Gene summaryThis gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 19   Locus: 19q13.4
Gene position55128629 - 55149007  Map Viewer
Gene orientationplus
Gene size20379 bp
Gene sequence
OMIM ID604811