Entrez gene ID | | 10972 |
Official gene symbol | | TMED10 |
Full name | | transmembrane emp24-like trafficking protein 10 (yeast) |
Aliases | | ,P24(DELTA),S31I125,S31III125,TMP21,Tmp-21-I, |
Gene summary | | This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q24.3 |
Gene position | | 75643349 - 75598171 Map Viewer |
Gene orientation | | minus |
Gene size | | 45179 bp |
Gene sequence |
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OMIM ID | | 605406 |