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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for METAP2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID10988
Official gene symbolMETAP2
Full namemethionyl aminopeptidase 2
Aliases,MAP2,MNPEP,p67,p67eIF2,
Gene summaryThis gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q22
Gene position95867822 - 95909615  Map Viewer
Gene orientationplus
Gene size41794 bp
Gene sequence
OMIM ID601870