Entrez gene ID | | 11035 |
Official gene symbol | | RIPK3 |
Full name | | receptor-interacting serine-threonine kinase 3 |
Aliases | | ,RIP3, |
Gene summary | | The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q11.2 |
Gene position | | 24809242 - 24805227 Map Viewer |
Gene orientation | | minus |
Gene size | | 4016 bp |
Gene sequence |
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OMIM ID | | 605817 |