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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LECT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11061
Official gene symbolLECT1
Full nameleukocyte cell derived chemotaxin 1
Aliases,BRICD3,CHM-I,CHM1,
Gene summaryThis gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 13   Locus: 13q14-q21
Gene position53313947 - 53277399  Map Viewer
Gene orientationminus
Gene size36549 bp
Gene sequence
OMIM ID605147