Entrez gene ID | | 1109 |
Official gene symbol | | AKR1C4 |
Full name | | aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) |
Aliases | | ,3-alpha-HSD,C11,CDR,CHDR,DD4,HAKRA,MGC22581, |
Gene summary | | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10p15-p14 |
Gene position | | 5238798 - 5260912 Map Viewer |
Gene orientation | | plus |
Gene size | | 22115 bp |
Gene sequence |
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OMIM ID | | 600451 |
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