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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ADAMTS13 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11093
Official gene symbolADAMTS13
Full nameADAM metallopeptidase with thrombospondin type 1 motif, 13
Aliases,C9orf8,DKFZp434C2322,FLJ42993,MGC118899,MGC118900,TTP,VWFCP,vWF-CP,
Gene summaryThis gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q34
Gene position136279459 - 136324508  Map Viewer
Gene orientationplus
Gene size45050 bp
Gene sequence
OMIM ID604134