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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ADAMTS5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11096
Official gene symbolADAMTS5
Full nameADAM metallopeptidase with thrombospondin type 1 motif, 5
Aliases,ADAMTS11,ADMP-2,FLJ36738,
Gene summaryThis gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq]
LocationChromosome: 21   Locus: 21q21.3
Gene position28339439 - 28290231  Map Viewer
Gene orientationminus
Gene size49209 bp
Gene sequence
OMIM ID605007