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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTPN21 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11099
Official gene symbolPTPN21
Full nameprotein tyrosine phosphatase, non-receptor type 21
Aliases,PTPD1,PTPRL10,
Gene summaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q31.3
Gene position89021123 - 88932122  Map Viewer
Gene orientationminus
Gene size89002 bp
Gene sequence
OMIM ID603271