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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP10 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID11221
Official gene symbolDUSP10
Full namedual specificity phosphatase 10
Aliases,MKP-5,MKP5,
Gene summaryDual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q41
Gene position221915461 - 221874766  Map Viewer
Gene orientationminus
Gene size40696 bp
Gene sequence
OMIM ID608867