| Entrez gene ID | | 11277 |
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| Official gene symbol | | TREX1 |
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| Full name | | three prime repair exonuclease 1 |
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| Aliases | | ,AGS1,CRV,DKFZp434J0310,DRN3,HERNS, |
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| Gene summary | | This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 3 Locus: 3p21.31 |
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| Gene position | | 48507229 - 48509044 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 1816 bp |
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| Gene sequence |
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| OMIM ID | | 606609 |
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