| Entrez gene ID | | 11298 |
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| Official gene symbol | | Aanat |
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| Full name | | arylalkylamine N-acetyltransferase |
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| Aliases | | MGC151344,Nat-2,Nat4,Snat |
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| Gene summary | | The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
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| Location | | Chromosome: 11 Locus: 11 E2|11 70.0 cM |
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| Gene position | | 116455001 - 116458994 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 3994 bp |
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| Gene sequence |
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