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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NLRP3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 114548 Official gene symbol NLRP3 Full name NLR family, pyrin domain containing 3 Aliases ,AGTAVPRL,AII,AII/AVP,AVP,C1orf7,CIAS1,CLR1.1,FCAS,FCU,FLJ95925,MWS,NALP3,PYPAF1, Gene summary This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq] Location Chromosome: 1   Locus: 1q44 Gene position 247579458 - 247612410  Map Viewer Gene orientation plus Gene size 32953 bp Gene sequence >NLRP3:41097237..41130189:Length=32953 GCATTTCCTCTCTAGCTGTTCCTGAGGCTGGCATCTGGGTAAGTCCAGCTCCGCGGGGCA GTGTGGGCGACAGGACCGGGAGAGCAGTGGGGGAGATTGTGTTCAGAGGGCAGAACTTGT CCTGGTTAATGCACTAGGAATTTCTTCTGGCGTCTCCAAGGTTGTGCTTCAACAACATTT CTGGAATGTTCTTTTATCATTATTTGGGCTCTACGTGTGCAAGTTCGTGTGTGTGTATGT GGCGGGGGGAAGCGGGGAGGACAGCGGCAGCAACCATAGTTTACACCCACGACTTCAGCA GATTTGCCCAGTATCCCTCCCAGGGGAGAAGATGGATGGGATATACAGAAGGAAACAAAC CTCCTTAAAGACCAAAGGGCAGCAGATTTTTGTGCTGGTGTTAGGGTGGAAGGAGCACAG AAGAAAGGCAGAATCCTGATGCAGATGGAAGGACTGATGGGGCAGGAGCTGGGAGGGTAT GCGGAGCTAATAGGGCTGTCTGGAGAGCAGTCACCTCAGGATGGGCAGGAGCTGGGAGGG TATGCGGAGCTAATAGGGCTGTCTGGAGAGCAGTCACCTCAGGATGCACAGGGCTGGGTT TGCAGGGCTCAGGAGGCGAGGAGTAGATAGGCAGGAATGGAGATGGGACGGGAGAGATGA GTGAGTCTGAGGCATCTTGACATTGAACTGCAGTCACAGAAATTCCAATTTGGAGAGCTC CACCGTTTTCCAGGCTCTCTGCCTCCCTTGAGTGTTATTTATGGCTTTAGGTTGAGGTGC TTTGCCAAATAGAGTATAATCAAGGGATCAAGGAGGGAACAATTCCAAACAAAGCCAACT TGTTCATCCATCCGGACTCTAGGAGATATGGAAGATCTAAAGATACAGCAGGTGATTGCT AGTTTTTGTGGAACTCACAGTCTAGTTGGGAAGACTATGTTGGTGAATGCTGCAGTGATA CACCTGTGATAAATGCTGGGGAAGTGTGTCTTTTAGTCATCTATTTTGTTGTCTTTGTCT TTGTCTGACTGAAACAAGTGATGGAAGACATGGTCTCATATCTCTGGTCAAAATCCTGGC TCTGTTCCTTCCTGGTTCTAAACCCCTCGGCAGGCTTCCTAGTCCCCCTAAGACTCAGTT TATGCATCTATAAAATGGGGCTAGGAATAGGTGCACCTCATAGAGCTCTGTGCAGGTTAG ATGGGGAAAAACATCAGTGAGTGCCTAGCCTGTGGAAAGCTCTAAATTAATGTGAATTAT AATGATAACAATTGCGAATTTTGCAAGGAGACATTAAAGGATGTATGTTTTTATTTATTT TATTTTATTCTATTTTATTTTTTGAGATGGAGTTTTGCTCTTATTGCCCAGGCTGGAGTG CAGTGGTGTGATCTTGGCTCATCGCAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGC CTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGGTACCATGCCCGGTTAATTTTTGT ATTTTTAGTAGAGACGGGATTTCTCCCTGTTGTTTGGTGAGCCTGGTCTCCAACTCCTGA CCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGGATGTATGTTT TTATTATTCTCCATTATGCACTCCCAGCTTCATCTCACTTCAATCCACTGGTTGATAGAA GTGCAGTCAAAGACTGTCCCCTCCTCTGCAAGCTTTTATGTTCTCTCTCCTCTCTCCCTA GCCACGTCCTGTTCTGTTATCAACACACTTACTCACCTCCTGGCCTTCTCCTTCTATTGT CTCTCATCCCTCTTCCCTCACAAAAACAGAAGCAAAGAGCCAGAGCCTTCAGTTTGGAGG AACTGAAAACATTCTCTTCTGCTTTCTCATTTTGTAGATGAGGAAACTGAAGTTGAGGAA TAGTGAAGAGTTTGTCCAATGTCATAGCCCCGTAATCAACGGGACAAAAATTTTCTTGCT GATGGGTCAAGATGGCATCGTGAAGTGGTTGTTCACCGTAAACTGTAATACAATCCTGTT TATGGATTTGTTTGCATATTTTTCCCTCCATAGGGAAACCTTTCTTCCATGGCTCAGGAC ACACTCCTGGATCGAGCCAACAGGAGAACTTTCTGGTAAGCATTTGGCTAACTTTTTTTT TTTTGAGATGGAGTCTTGCTGTGTCGCCTAGGCTGGAGTGCAGTGGCGTGATCTTGGCTC ACTGCAGCCTCCACTTCCCGGGTTCAATCAATTCTCCTACCTCAACTTCCTGAGTAGCTG GGATTACAGGCGCCCGCCACCACACCCGGCTCATTTTTGTACTTTTAGTAGAGACACAGT TTTGCCATGTTGGCCAGGCTGGTCTTGAATTCCTCAGCTCAGGTGATCTGCCTGCCTTGG CCTCTCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTTGGCTAACTTTTC AAAATTAAAGATTTTGACTTGTTACAGTCATGTGACATTTTTTTCTTTCTGTTTGCTGAG TTTTTGATAATTTATATCTCTCAAAGTGGAGACTTTAAAAAAGACTCATCCGTGTGCCGT GTTCACTGCCTGGTATCTTAGTGTGGACCGAAGCCTAAGGACCCTGAAAACAGCTGCAGA TGAAGATGGCAAGCACCCGCTGCAAGCTGGCCAGGTACCTGGAGGACCTGGAGGATGTGG ACTTGAAGAAATTTAAGATGCACTTAGAGGACTATCCTCCCCAGAAGGGCTGCATCCCCC TCCCGAGGGGTCAGACAGAGAAGGCAGACCATGTGGATCTAGCCACGCTAATGATCGACT TCAATGGGGAGGAGAAGGCGTGGGCCATGGCCGTGTGGATCTTCGCTGCGATCAACAGGA GAGACCTTTATGAGAAAGCAAAAAGAGATGAGCCGAAGTGGGGTGAGTGGAAGGAAGACT TTTAAAAAAAATTGTGGCCAAGTGCACATAGTGTACAATTTTCCATCTTTATATATATAT ATATATATATTTTTTTTTGAGACGGAGTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGT GAGATCTTGGCTCACTGCAACCTCCACCTCCCGGGTTCAAGCGATTTTCCTGCCTCAGCC TCCCAAGTAGCTGGGATTACAGGCATTGCACCTCCACGCCCGGCTAATTTTGTATTTTTA GTAGAGATGGGGTTTCTCCATGTTGGTCAGGTTGGTCTCAAACTCCCGACCTCAGGTGAT CCACCCGCCTCGGCCTCGCAAAGTGCTGGAATTACAGGTGTGAGCCACCGCGCCCGGCCG TAATAATTTTTAAATGTACAGTTCAGTAGTGTTAGGTACACTCACATTGTGCAACCAGTC TCCAGAACTGTTTTCATCTTGCAAAACTGAAACTCCTCACCCATTGAATGATAACTCCTC ATTGCCTCATTCTCCCAGCCCTGGTAACCACCATTCTATTTGCCATCTCTGTGAATCTTA CTACTCTGGGTACCTCATATAAGTGGAAACATACAGCATTTTTTCCTTTATGAGTAGTTT ATTTCACTCAGCATAATGTCCTCCGGGTTCAACTATGTTGTAGCATGTGTCGGAATTCCC TTCCTTTAAAAAAGACTGTATAAATACTCCATGGTACCATATACCAAATTTTGTTTAGTT ATCTGTTGATGAACACCTGGATTACTTCTACCTTTTTGTTATTGTTAATGCTGTTATGAG TGTTGGTGCACAAATATCTCTTCAAGACCCTGCTTTGAATTCTCTGGGGTATATACTCAG AAGTGAAATTTCTGAATCATACGGTAATTCTGTTAAATATTTTGAAGAACTGCTCTACTG TTTTAGATACCATCTGCACCATTTCCCACCAACAGCACACAAGGGTTCCAATTTCTCCAT ATCCTAAGAACACGTTATTTTTATTTATTTTTTCTTTTTTATAGTAGCCATTCTAATGAG TGTGAGGTGGTATCTCACTGTAGTTTTGATTTCCGTTTCCCTAATGATAAGTGATGCTGA GCACATTTTCACTGCTTGTTGGCCATTTATAGAGCTTCTTCAGAGAAAGTTCTGTTCAAG TTCTTTTCTCATTTTCAGACCAGGTTTGGCTTTTGTTGTTGCCTTGTAGGAGTTCTTTAT GTATTCTAGATATTAACCCCATATCAGATATATGATTTACAAATATTTTCTCCTATTCTG TGGGTTGTCTTTTCATTTGGTTAACTGTGTCCTTTGATGCACAGAAGTTAGTATGATTTT TTTTTTTTTAAATCATGGCCGGGCATGGTGGCTCATGCCTGTAATTCCAGCACTTTGTGA GGCTGAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAACACCAGCCTGGCCAACATGGCA AAACCCCATCTCTACTAAAAATACAAAAAAAATTAGCCGGGTGTGGTGGTGGGCACCTGT AATCCCAGCTACTCAGGAGGCTGAGGTAGGAGAATTGCTTGAACATGGGGAGTGGAGGTT GCAGTGAGCTGAGATTGCACCACGGCACTCCAGCCTGGGCTAAAGAGCAAGACCCTGTTT CAAAAAAAAATTTTTTTTTCTTGTATTGTCTTGGTTTTTTCTCTTTTCCCCTCTCACGGT AGTGCTATGAGAAGGTGGAGGCAAACTGTTTGCTTTCTCTAACTCCTTTAAAAAGCTGAT GCAGACTGTACCTACCCCCTGGGCACCTGCCATGATTAGTCCCTCTTTATCTGAATCTCA GCAGTGCCTAGACCTGCCTCCAATTCTCCATCCAGCTTCTCAGACCACATGTTTTGTCCA GTATCTGCTGTGTGGTCAGCAGGCTTGGGCCTCTGCTTCCTATGGCCCAGAGGGCAGCCT CTCTCCTTGAAGAACCGTGGAGTTTGGGGCAGAAGCCTTTCCTTTCACCACCACTTTGGG AATTGGAATGTAAAAGAAATTCTCTTAATCCCCATGTACACATTGGGGATAAGGTTCTTT CTTTTGTCTTGTGTTCTAGGCAAAGGTAGGGCTCAGAGAAGGGCAGGGTATTGCAGGATG ATGATGTAGAGCTGGTGGTGATGGGAAGGAGGAGTACAAATGAGTCAGTGGATAGGGAGA CACATGTTAAGGCAGGGCAGCAGTGTGGGTGTAATGACACTGGGGAAACAGACAGCAGTG TGCAGCCGGGGGAGGTCAGAAACCAGTTGCTGCAATGGCTCTCACCTGTAGTCCCAGCTA CTCAGGAGGCTAAGGCAGGAGGATCGCTTGAGCCCAGGAGCTCAAAACCAGCCTGAGCAA CATAGGGAGACCTCATCTCTAAGTAAATAAAGCAATTATCATTGTGTCAGTACTTATATA CTCACATACCCAAATGAAAGTGTCATAATCACAACTGTAGAAGTACTTTGCTAAGCAGTT TTTATGGATTTTATGGCACATTCAAGAAACCCATGAAACAGCTTCTGGTATTATCCCTCC TGCAAGTGAATGAGGTGAGCCTGGAAGAGATCCTAACTGGCCCATGGTTTATTTCTAGCC ATAACCAGAGCTGGGGTAAAAAGCAGGGCATGTCTCTGATCAAAGCCTGGCTCTTAACCA CTACACCGTCTTTGCTTCCATATCTGGATTTTGAGGCAGAAAAGTTATAACTAGGGTTAG AAGTTTGTTTGTTTGTTTCCTGGGGTGGGGTTAGGTTTTAGGTAATAGACTTTGGCTAAT TTACTGTCATGGCTCCTACCTGAGTCCCAGTTACTCAGGTGGCTGAAGTGGGTGCATCAC TTGAGCTCAGGAGTTCCAGGCTGGAGTGAGCTATGACCATGCCACTGCCCTCCAGCTTTG GAAACAAAGCAAGACTCTGTCTCTTAAAAAAAAAGAATAAGATTTTGGTTTTGGCTTAGA TTTTTTGGATTTTATTTTGTGATATGGTTACCAAGTAGACAGCTGTCAGAGGTCTTTTAT GGGCTGGGCGCAGTGGCTTATGCCTGTAATCCCAGCACTTCAGGAGGCCAAGATGGGAGG ATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGAACCTGTCTCTAC AAAAAATGCAAACATTAGTTAGGTGTGGTGGCACGTGTCAATAGTCCCAGCTGTTCTGGA GGCTGAGGTGGGAGGATCACTTGAGCCCAGGAGGTTGAGGCTGCAGGGAGCCATGATTGT GTCATTGCACTCCAGCCTGGGCAATAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAAAAT CATTTATGTTACTTGTAGATTCCTGCCCACCTGAAGTTATCTGTCTTATATATTTCCCCT AGTGACTAACTCTTGTTTTACCTAACCTGAATTTCTCCTATAGAATGCCTTCTTAAGATA TGCTATCTAGTGACTGTTTGGATTTGTGATTCTCAACACAGATGCATGTTGGAATCACCT GGGAGCTTTTAGTATGTGATGGTTCCTGGGCCTCACCTCAGAGGGACTGAAAAAGAACCT CTGGGCGTGCAGTCCTGAAGTCCATATTTTTAAAGCTTCCTGGGTGATTCTAAAGTCAGC CAGGATTCCCAACCACTAGATTAGGCACGAAATAGACTGGTCGTTCTCACTCTTGAAGAA CCAGACATCTAGACTTGACAATAGAAGACGTGTGTAAAATGGATTGCAGGGAACTGCGGT CAGGGAAGGGTGACCTTTCTTAGCCCACAGCCGTGTTGGGGATATAGGAGAGCTTGGAGA TGCCCTCACAATCAGGCTGCCAGGGGCAGGCAAAAGCAAACGAGGGTAAAAGAAACTTAG CCTGCTTCGCATGTTTGCTGATTGATTTCCAGGCCTGAGGAAGAGATTCTGAGACTGGGG ACAGTGGGAACACATGCTTGGCAGGTGGACAGCAGAAGTTGTTTTGAAACTAGGAGTGCA GAAATGCTCCCAACCAGACTTTTGACTGGATACCTGTCCTCTGCAACTCAGAGCCATGTT TTGATTTGGGGGATGTTTGGGGTCTCCTCTCTCATGCCAAATATTAGGCCAGGTTTCAAT TGCATCCTCTGTGATAATAGTTCTGGGTTTTGACACCTTTTTTTTCCCTTTTAGGTTCAG ATAATGCACGTGTTTCGAATCCCACTGTGATATGCCAGGAAGACAGCATTGAAGAGGAGT GGATGGGTTTACTGGAGTACCTTTCGAGAATCTCTATTTGTAAAATGAAGAAAGGTAAGC GACTGGGGTGGTGCTTCTAGTTGAGTTTTAAGACCTGGTTCAGGAGGCTCTGGGAAGCTG AGCAGCTGGGTAACTTGGCCATACTATAGGTTCCTGCTCTTTGGAATGCAAAGGCCTGTC TCAGGAAATCCATTGTCAGTTGAAGAAACAAATTCATGTTTGTGTGGCTCTTGCAGTCCC AGAGCCAGCGGCGGTGATTAAGCGTTTCAAGTTTGATAAGGCATAGGATGCAGATTACTT AAAGGAATAAGATTGATTCAAATGATCTTTGGGCTGGTAGCTACACATAGAGATGGGCCT TCTGCTCAGCTGTGTATCTTAAAAACTTGACACCAGAGATTCTCGGCACCTTTCCTACCC AGTGGGGAGGAGCTGCACCTTCCATTTCTCCATTCCGGTTACCACTCGCTTCCGATGACA GGCCCCAGCTGAGAGCGCATCTCAGGTGGATGTGTGTATACTTTCCCCCTAACTTCCTGT CTTTGCCGTAGATTACCGTAAGAAGTACAGAAAGTACGTGAGAAGCAGATTCCAGTGCAT TGAAGACAGGAATGCCCGTCTGGGTGAGAGTGTGAGCCTCAACAAACGCTACACACGACT GCGTCTCATCAAGGAGCACCGGAGCCAGCAGGAGAGGGAGCAGGAGCTTCTGGCCATCGG CAAGACCAAGACGTGTGAGAGCCCCGTGAGTCCCATTAAGATGGAGTTGCTGTTTGACCC CGATGATGAGCATTCTGAGCCTGTGCACACCGTGGTGTTCCAGGGGGCGGCAGGGATTGG GAAAACAATCCTGGCCAGGAAGATGATGTTGGACTGGGCGTCGGGGACACTCTACCAAGA CAGGTTTGACTATCTGTTCTATATCCACTGTCGAGAGGTGAGCCTTGTGACACAGAGGAG CCTGGGGGACCTGATCATGAGCTGCTGCCCCGACCCAAACCCACCCATCCACAAGATCGT GAGAAAACCCTCCAGAATCCTCTTCCTCATGGACGGCTTCGATGAGCTGCAAGGTGCCTT TGACGAGCACATAGGACCGCTCTGCACTGACTGGCAGAAGGCCGAGCGGGGAGACATTCT CCTGAGCAGCCTCATCAGAAAGAAGCTGCTTCCCGAGGCCTCTCTGCTCATCACCACGAG ACCTGTGGCCCTGGAGAAACTGCAGCACTTGCTGGACCATCCTCGGCATGTGGAGATCCT GGGTTTCTCCGAGGCCAAAAGGAAAGAGTACTTCTTCAAGTACTTCTCTGATGAGGCCCA AGCCAGGGCAGCCTTCAGTCTGATTCAGGAGAACGAGGTCCTCTTCACCATGTGCTTCAT CCCCCTGGTCTGCTGGATCGTGTGCACTGGACTGAAACAGCAGATGGAGAGTGGCAAGAG CCTTGCCCAGACATCCAAGACCACCACCGCGGTGTACGTCTTCTTCCTTTCCAGTTTGCT GCAGCCCCGGGGAGGGAGCCAGGAGCACGGCCTCTGCGCCCACCTCTGGGGGCTCTGCTC TTTGGCTGCAGATGGAATCTGGAACCAGAAAATCCTGTTTGAGGAGTCCGACCTCAGGAA TCATGGACTGCAGAAGGCGGATGTGTCTGCTTTCCTGAGGATGAACCTGTTCCAAAAGGA AGTGGACTGCGAGAAGTTCTACAGCTTCATCCACATGACTTTCCAGGAGTTCTTTGCCGC CATGTACTACCTGCTGGAAGAGGAAAAGGAAGGAAGGACGAACGTTCCAGGGAGTCGTTT GAAGCTTCCCAGCCGAGACGTGACAGTCCTTCTGGAAAACTATGGCAAATTCGAAAAGGG GTATTTGATTTTTGTTGTACGTTTCCTCTTTGGCCTGGTAAACCAGGAGAGGACCTCCTA CTTGGAGAAGAAATTAAGTTGCAAGATCTCTCAGCAAATCAGGCTGGAGCTGCTGAAATG GATTGAAGTGAAAGCCAAAGCTAAAAAGCTGCAGATCCAGCCCAGCCAGCTGGAATTGTT CTACTGTTTGTACGAGATGCAGGAGGAGGACTTCGTGCAAAGGGCCATGGACTATTTCCC CAAGATTGAGATCAATCTCTCCACCAGAATGGACCACATGGTTTCTTCCTTTTGCATTGA GAACTGTCATCGGGTGGAGTCACTGTCCCTGGGGTTTCTCCATAACATGCCCAAGGAGGA AGAGGAGGAGGAAAAGGAAGGCCGACACCTTGATATGGTGCAGTGTGTCCTCCCAAGCTC CTCTCATGCTGCCTGTTCTCATGGGTAAGGAAACTCGGCTTCCAGGTGCTTCCTCCTGCT TCCTCGCCAGCTTCTTCTTGGCGCTTGCCTCCTCTCATCTCTTTTCAACTATCTTCCAAA TACTGTTGCCACAGCTACATCATAATGCCACCACTGTCTGTTTGAGACTCCTTCATGAGC AAAGATTGATGTATGGTAGGTGGATAAATGGGATGAGGAAAAAAAAAATAAAACAAGGAA CAAATGTTTGGGGAATGCCAGTTTAGCACAAGGTATTAAGTAGGATGTAGGATTGCCTAC AAATATTTGTCAACTGAAATTTCTTGTAAGCTACTTGGAGCACTAGTGCCTAAGAGTCAG TCAATGTCTGTGGGGCAGAACAATGCCAGAGAGTCTGTGTCCCAGGAGCGAGGGGACAGA GGGCCTCAGAGCTGGAGGCTGGGGGGATGTTTCTTAGAAATGTGCAATCTAAGCCTCCTT TAAGGAATGGTGGGACCTGGGCGCATAGAGAAGAAATTAAAGGAATTCTGCACTGAAGAC TGGTATGAGCCAAATCATGAATGCAGTCTGAGAAAAAGTGTGTGCAGGTGACAGTGGAGA GAGACACAGTTTCCTTGGAAAAAAACATGATGAAGGTAAATCAAGGGAAATAGAGCAGAA ATGTGGAGACCCTCTTTCTAGGCCCCCATGTTGCTCTGCACTGGGCATTGCCAAAACCCC GTTTTCGGGTCTGTTCACACACTTGCTGGGTGGTTGGAAGCTAGTGGCCAAGTCTGTGCA ATGAAGTGGTTGAGTCACCTGACTTCTGAGTCCCTTTTGGGTTTATCGTTCAGTGCCTCC TGCAGAAGGACCACCCACAGTGGTTGTAGGAAGGTGGCCACCCTGTGATGTGTGAGTTTA GCCTGGATAGAAGACACTTGACGTGGGGCAAAATTAAGGGAAACAGGAGGCTTGGCCCTT CCACAGGCAACAATGAGTTTCAGCTTTCTTGATCCGTTGACATTACCATGACCAGGACCA CCTTCCTAGTCATGGTTTGGCCATGAAGGACTGACTGCCCACAGGGCCGCAGTGGTGGTG AAGACCCAGGTCCTGGTCACAGGGACTTGAGGTCTGGCTGTGGGACAGTCCGGAAACAAG TGCAGATGTCGGGGAGGGGGTCATGGGCTCTGACAAGGAAACTTGCAGAGTATCCAAAGC ACAAGGGGACGAACCTGTTCACCAGCGGGGCACGGGTGGGTGTCCCCGCTCAGCCAGCTT CCGGAGGATGGGCAGTGAGAGAGTGAGAGAAGGAAAGGGGCAGCCAGGCTGGGGGCTTAC GGTGTTGAGAGAGAGGGCAGGTGTGGGAAAGCAGGGTACGGTTTCTACGGCAGCAAACAG TTCCGAGTGACTGGAAAAAAGACAGTTGTCTTCATTCATCAGGTTGCCATAACAAAACAC TGCAGGCTGGTTGGCTTATAAGCAAAAGGAAGGTTCACCTTACGGTTCTGGAGGCTGGGA AGTCCATGATCCAGGCTCTGGCAGATCTGGTGTTTGGTGAGGGCCTGTTCCCTGGTCGAT GGTGCCTTCTCACTGTGTCCTTACATGGTGAAGAGGCAAGGCAGCTCTCTGGGGTCCCTT TCCTAAGGACAGCAATCCCACTCCTGAGGGCTCCACCCTCATAACTTAACCACACCTCAA AGGCCCCATCGCCTGATACGTCATGTTGAGGGTTAGGATTTCAGCGTATGGATTTTGGGG CACACAAACATTCAGACCATAGAAATGGGAGAAGAAGAGTAAGACAGAGAGAAAAGTAGG CAGAACTACTCATTAAGAGTGAGGTGGAAGGTGGAGAGGGCAGGGAGACCTTATGAAGAT CACACATCTGTGAGGAAGGTTTGCACACTCTCACTGAAGCCCCGGTAGGAGGCTCAGCAC CCATTTCTCTAGATAGCACCTTCCTTCCTCTGAGGACAGATTCTGACTGGAGCCCTGGTA GGGGGCTCAGCACCCATCCCTCTAGATGGCACCTGCCTTACTCTGAGGACAGACTCTCAC TGAAGCCCCGGTAGGAGGCTCAGCACCCATTTCTCTAGATAGCACCTTCCTTCCTCTGAG GACAGACTCTGATTGGAGCCCTGGCAGGGGGCTCAGCACCCATTTCTCTAGATAGCACCT TCCTTCCTCTGAGGACAGACTCTCACTGAAGCCCCGGTAGGAGGCTCAGCACCCATTTCT CTAGATAGCACCTTCCTTCCTCTGAGGACAGACTCTGATTGGAGCCCTGGCAGGGGGCTC AGCACCCATCCCTCTAGATGGCACCTGCCTTACTCTGAGGACAGACTCTCACTGAAGCCC CGGTAGGAGGCTCAGCAACCATTTCTCTAGATAGCACCTTCCTTCCTCTGAGGACAGACT CTGATTGGAGCCCTGGCAGGGGGCTCAGCACCCATTTCTCTAGATAGCACCTTCCTTCCT CTGAGGACAGACTCTCACTGAAGCCCCGGTAGGAGGCTCAGCACCCATTTCTCTAGATAG CACCTTCCTTCCTCAGGACAGACTCTGACTGGAACCCTGGTAGGGGGCTCAGCACCCATC CCTCTAGATGGCACCTGCCTTACTCTGAGGACAGACTCTGACGGGAGCCCTGGTAGGGGG CTCAGCACCCATCCCTCTAGATGGCACCTGCCTTACTCTGAGGACAGACTCTGACTGGAG CCCTGGTAGGGGGCTCAGCACCCATCTTTCTAGATGGCAGCTGCCTTACTCTGAGGGCAG GAGCTTGCTTTGTATGTTCCAGTCCCTTCTGAGAACCAGAAGCCTGAGCATCTATTAGAA ATGCAGGATTGTGGACCCAATCTTAGACCTAGAGAGCTAGACTTTGCATTTGAATGAGAG CTACAGGTGATTCAAAGGTGACTGCATGTGTGGGTGCAGTGGCTCTTGCCTGTAATCCTA GGTTTTGGGAGGCCAAGATGGGGGGATTGCTTGAAGCCAGGAATTCAAGTCCTACCTGAG CAGCAAAGTGAGAGCACCTCTCTACAGAAAAACAAAAGCAAAAATGTGACTGCATGTTGG AGCCACCTGGCTTTTTTTAAATAAAAAAGATCCATATAGCTGGACACAGTGACTCGTGCC TGTAACCTCAGCTACTCGGGAGGCTGAGGCAAGAGGATTGCTTGAGCCCAGGAGTTTGAG GCTGCAGTGAGCTATGATCATGGCACTGCATTCCAGCTTGGGTTTCATCTGAAAAAAAAT TTAAAAAATTCATCTAGTTCCACCTCAGAGCTTCTGATTTTATTTCCATGGATGTGGCCT GGGCTTGCGATTTTCTTTTTCTTTTTTTTTTTTTTGAGATGAAGTCTTGCTCTGTTGCCC AGGCTGGAGTGCTGTGGCATGATCTTGGCTCACTGCAACTTCCACCTCCCAGGTTCAAGT GATTCTCCTGCCTCAGCCTCCCTAATAGCTGGGATGACAGGCTCGTGCCACCACACCCAA TTAATTTTTGTATTTTTAGTAGAGAGAGGGTTTCACCATGTTGGCCAGGCTGATCTTGAA CTCCTGACCTCAGGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTG AGCCACCATGCCCAGCCTGGCCTGAGGATTTTTGTGAGCACTCCTGATGCTGTTGTGTAG CCAGGAGTGAGGACTGCCCTCTGATCACCCAGCACAGAACGTTCAGGGCCATGTTGGGAC AGTGGACTGGTAAGGGCGAGAGGAGGACACTGGGGAGCAGGCTGTAGGGTGCCACAGTCC GCCACAGTCACAGGCTCATGCTCTCCGTCCGAGAGGAGGCAGAACTGCTTTTACCAAGGC TCATCCAGCCCTCTTCATTTCTCTGGGAACAATTTTTGGTTTCGTGACCCATTTCTTAAT CCCCGGAAGGCATTTCTCTGAACTGGTGCCAGGCACCCCGGCCCCCAGCTCCAGTTAGTT ATTATTCGAGGCTGATTTCTTTTCTGTCTGTCTTCCTTCTAATTCCTAGATTGGTGAACA GCCACCTCACTTCCAGTTTTTGCCGGGGCCTCTTTTCAGTTCTGAGCACCAGCCAGAGTC TAACTGAATTGGACCTCAGTGACAATTCTCTGGGGGACCCAGGGATGAGAGTGTTGTGTG AAACGCTCCAGCATCCTGGCTGTAACATTCGGAGATTGTGGTGAGTCCCCGTGCATGTGA TCTGTGTGAGTGCAAGTTCATATGAGAGAGAGAGAGAGAAACAGACTGGAGAAAGATCTT CAGGACCAGGTTGCTGGTGTGGTTTCTTTCTTTTCTTTTTCTTTTTTTCTTTTTTTGAGG CAGAGTTTTGCTCTTATTGCCCAGGCTGGAGTGCAATGCCGTGACCTCGGCTCACTGCAA TCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTAC AGGCACCCACCACCATACCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCATC ATGTTGTCCAGGCTAGTCTCGAAGTCCTGACCTCAGGTGATCCGCCCGCCTCGGCCTCCC AAAATGCTGGGATTACAGGCATGAGCCACCGCACCCGGCCGGTGGTGTGGTTTCTGCTGT AACAAAGTGCCACAGACTGAATGGCTTCAACAACAAAAATTCATTTTCTTGCAGTTCTGA GGCCGAAAGTCTAAGATCAAGGTGTCAGCAGGGTTGGTTTCTTCTGAGGCCGCCCTCCTT GGTTTGTAGATGCCCCCTTCTCCCTGTGTACTGATGCCATCTTGCCTTGGGGGGAAGAGT GGCCTAGTCTCCTCTTCTTACAGGGACAGCAGTCCTGATGGATTAGGCACAGTCAGGCAT GACTACACAAGACCTAATGTTAATCTAGTCACTCCTTTAAAGACCCCATTTCCCAAAACA GCCACATTATGAGGTCTTGAGGATTAGGGCTTCAACATGTAAATTTTTGGGGGGGCACAG TTCAGCCCAGAACAAGTGAGAAGGTAGAATGGGTTGGAGGCCAGCTGGGGAAGTTTTGTG TGGGGAAGAATGAATGAGGAACTAAAAAAAAAGTCATTTCTTGAAACAACCATGATGCTC GATATATTCCATTTCCTCATGGGCCATGTTCATAGATGAGAGTTGGAGAATTTGCCATTT ACAACAATGGCAACCTCACCTAAAAACTATGAAAATACTTTTTTTTTTTTTCTTTGAGAC AGGACCTCTCTCTGTCACCCAGGCTGGAGTGTGTGATCACAGCTTACTGCAGCCTCGACC TCCCAGGCTCAAGCAATCCTCCCACCTCAGCTCCCCCGAGTAGCTGGGACTACAGGCATG CACCACCATGCTGGCTAATTTTTGTATTTTTTTTGTAGAGATGTGGTCTCATCACGTTGC CCAGCCTGGTCAGAATGCTTTGTATGGGTTGAAATGTCACAGGGAATCTCCTGTGACTTT ATTAATAATGTGCTTGCTCACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGA ACTGTGTGTACCCGGGAGGCGGAGATGGCAGTGAGCCGAGATCGTGCCATTGCACTCCAG CCTGGGTGACAGAGCGAGATTCCATTTCAAAATAATAATAATAATAATAATAATAAAAAA TGTGCTTGCTTTCTCCCACACCATGAATCAGATTCACACGCCCCACCGCGCTGGTGCCTG GGCCGCCTCACTAGCTCTGTTTCATTCCCTGCTCTGTGGACGCATGCAGGCGTCTGCATT TTTGAGGAGCTGCACAGCAAGTGTTAAAGTCCGCCACTCTAGGACATTTTGCTACCTCCC TCTCCGGCTCAACACACTCACCTTGTCACCAGTCTTATCAATTTTTCCTCCTACCCGAGC TGTTTTCCACTTTTCCTCGTCCTCACCCCACCAGCCCAGGTCCAGCAACTGTCACCACTT GCCTGGACACGCAGTGACCTCCTAGACCATCAGCTCCCCGGGGATGGGGTTTGCGTTTGT TTGTCTTGCTGTCATCTTTGCCACGCCTGGACAGACATCTTAGTACCCATCAGTGGTCAA AAGCACGCACTGAATGAATGTTGGCTCTTTGGTCTCCCTGTGTCTGCCTTTTTCCCTCAC CCGACCATTCTCTGCACAAAAGTAAGATGGTCCTTTAGAAAATTCTGATTCGATTGTGCT GTTCGGTGGCTTAAATGCTTTCTGTCTGCTCTGCTCTTTATTTTTTACTTTATGTATTTA TTTTTGTAGATGTAGGGGGCGCAAGAGCAGCTTTGTTTCATGGATATGTTACTGCACAGT GGTAGTGTCTGGGCTTTTACTGTAACTACCCCTTTTTTTTTGAGATGGACTCTCGCCGTG TTGCCCAGGCTGGAGTACAGTGGAGTGATCTCGGCTCACTGCAACATCCACCTCCTGGGT TCAAGCAATTCTTCGAGTAGTTGGGATTACAGGCATGGGCCACCACGCCCAGCTGATTTT TGTATTTTTAGTAGGGACAAGGTTTCACCGTATTGGCTAGGCTGGTCTCAAACTCCTGAC CTCGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTG CCCGGCCTTAGTGTAACTCTTACCCAAATAGTGAACATTGTACCCAATAAATAATTTTCC AGCCCTCACCTGGCTCCCACCCTCCCACCCTTCTGAGGCTCTAGTGTCTATCATTCCATG CTCTATGGATGTTACCCTTTGTTTAGCTCCCACTTGTAAGTGAGAACGTGTGGTATTTGA CTCTGTTTCTGAGTTGTTTCACTTAAGGTAATGGCCTCCAGTTCCATCTGTGTGGCTTCA AAGATGTGACTTCATTCTTTTCTATGGCTGAGCAGTATTCCATTATGTATATAGATCACA CTCTTCATCTTTGCTCTTTTGGTAAATTTCAAATCGTAGTGCCATGGAGACTGGTTGTTT GGGACATTTAACCTTATTTCTCCAACTTCATGCCCAAATTCTCTCCCCACTGCCATTGCC CCTGTATGATTCTGGAGAGGCAGACACAAACAGGGAAGGGTAGGGGACAGTGAGATGCTT CGCAGAGAAGTAGAGATCCATTTGTCCATTTGCTTGAAGTTGGTGTAAGGATAGGGACAG AAAGGAAGGTGGTCTAACAGGCTCCAGGACCTATGAACTATTGCCCTGGAAAGAAGCTAG AATGTTGTTCTTGCCCCCATGACAGGGATAAAGTATAGTTTTTGTTGCTGGTGGTGGTGG TGACGGTGGTAGTGATGTGCGTGTGTGTTTGTGTGCATGTGTGTGACGGGGAAACTAATC AAGAATCAGAGCTGCAGCGGGATGTGGAATCCCAGCACTTTGAGAGGCTGAGGTGGGCAG ATCACCTGAGCCCAGGAGTTCAAAACCAGCCTGAGCAAGCTGGTGAGACCTTGTCTTTAG AAGATAATAATAATAATAAAAATAAAATATAAATAAAATAAAATGGCTAAGCATGGTAGC ACATGCCTGTATTTGCAGCCACTTGGGAGGCTGAGGCAGGTGGATCCCTTGAGCCCAGGA GTTCGAGGTGGCAGTGAGCTATGATCTCGCCAGTGCACTCCAGCCTGTGCAACAAAGTGA GACCCTGTCTTTAAAAAAAGAAAAGAAAAGAAAAGAAAAAGAATCAGAGCTGCTTTTCCT TTCAATATAGATGGAGGGCTGGGATGAAATCGTCAAACACAATGGGGTGACAATGTTGGT GAAGACAAGAAATAGCTGAGTGCAGCACTGGCGAGGGCAGTGCCGACTGCGGGCACGTCA ATGGTTAGGAACACGAGGGAAGGAGGTGGGTGCACAGGCCCACACCGCCCGCTTCACTTA CAAACCAGGAGCGCACCATTCACATGTCTGGGGGGTGATCTCAATGCACCCGGCACTGTT TACGGCCGGGAGTTCACTGACAGGTGATCCCTCTGCTGTGACTGGGGAGACTGGGGGCTG ACCTCCCAATGTGCCTTGTGCTGTATTCCGGAGCTCTCTGGTCAGGTGTATTCTGATGCT TTCTCTATTCCAGAGCTCTCTGGTCAGGTGTGTCCTGATGCTTTCTCTATTCCAGAGCTC TCTGGTCAGGTGTGTCCTGATGCTTTCTCTATTCCGGAGCTCTCTGGTCAGGTGTGTCCT GATGCTTTCTCTATTCCGGAGCTCTCTGGTCAGGTGTGTCCTGATGCATTCTCTATTCCA GAGCTCTCTGGTCAGGTGTGTCCTGATGCTTTCTCTATTCCAGAGCTCTCTTGTCAGGTG TGTCCTGATGCTTTCTCTATTCTGGAGCTCTCTGGTCAGATGTGTTCTGATGCTTTCTCT ATTCCGGAGCTCTCTGGTCAGGTGTGTTCTGATGCTTTCTGTATTCCGGAGCTCTCTGAT CAGATGTGTTCTGATGCTTTCTCTATTCCGGAGCTTCCTGATCAGGTGTGTCCTGATGCT TCCTCTGTTCTGGAGCTCTCTGGTCAGGTGTGTTCTGATGCTTTCTGCCTCTGTTCTTGG CATGAAGGTTGGGGCGCTGTGGCCTCTCGCATGAGTGCTGCTTCGACATCTCCTTGGTCC TCAGCAGCAACCAGAAGCTGGTGGAGCTGGACCTGAGTGACAACGCCCTCGGTGACTTCG GAATCAGACTTCTGTGTGTGGGACTGAAGCACCTGTTGTGCAATCTGAAGAAGCTCTGGT GAGTCGAGCCCGTTCCCCTAAGGAAGTTCTGCCAGCGAGGCGTGCTGCGCACTCTGGCTT CAGTGAGGCCCGGTGGGCTGGGGTTTGAGTGAGAATGGCCTTGGCGGCTCGGGTGACTGC GTGTGCTTGTCTTGGGGTGTCTAGCATTGCGGTCAGTGAGTGTTTGTCGTGGGGAAAGCC ACACACTCAACCCTGACAAGGAGCATAAATAATAACAAAAAGAAGATGTCTGCCTTTAGG GTGCCTACTGCCTAGCTGACAAAAAGAAAAAATCAGTGTAATGCATTGCTTTAGAGGAGT TTTAGAACTTCATGACAAGCCCTGGGTCCTCATATTGTATAAGAAAAATGGTGCTAAAGC AATGCAGACCCTCGATGTTGTATGCAGCCCTTCCCTGAGTGCTTCTGGGAGACTTGCATT TTGAAGGAGAGAAAAAACCACTTAAAAATGGAAGGGCCATTTCTCACCCATTAGGATGGC TATTATCAAACAAAAGCAAGAAAACTAGAAAACAACAAGTATTGGTGTGGGTGCGGAGAA ATGGAAGCCATTGTGTGTTGCTGGTGGGAATGTAAATGATGCAGCCACTATGGAAAACAG CACAGCAATTCCTAAAAAATAAATACAGAATTACTACTGGAGCCAGCATTTCCACTGCTG GGTATATCTGCAAAAGAGTTCAAAGCAGGAACTCAGCCAGGAGCGGTGGCTCACACCTGT AATCCCAGCATTTTGGGAGGCTGAGGCAGGTGGATCACTGGAGGTCGGGAGTTCGAGACT AGCCTGGCCATCATAGTAAAACCTTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATG GTGGTGCATGCCTGTAATCCCAGTTACTCGGGGTGGAGGCAAGAGAATCTTTTGAACCTG GGAGGCGGGGGTTGCAGTGAGTCAAGATCCCGTCACTGTACTCCCGCCTGGGTGACAGAG GAAGCATTAAAAAAAACAGAAGGCAGGAACTCAAACATGTTATTTGTACATCTATGTCCA TAGCAACACTATTAGAAATAGCCAAAAGGTGGAAATAACCAAACGTCCTTCAACGGATGA AGGGTGTTGAAAAGTGCTATATATGTACATTCAGCTTTAAAAAGAATTCTAGTACACACT ACAACATGGATGAGCCTCGGGGACATTATGCTAAGTAAGATAAGCTAGACTCGAAAGGGC AAATACTCTGATTGTCCTTATAGGAGGTGTCTAGAACAGACAGATTCATAGAGACAGGAA GAAACGTGGTTGCAGGCAATGGGAGGGCGGAGAGTGGGAAGACATTGTTTAATGGTTATG GAGTTTCAGTTCTGCAAGATGAAAGGAGTTCTGGAGATGGTGGTGGTGATGGTTGCACAA CAATGTGAAGTGCTTAAGGCCATTAATTGTGCACTTAAAAATGGTTAAAATGGTAAATTT TATTTTACACGTATTTTACCACAATAAAGCTGAATGTAGGGAGCTGGGAAGATGTAGTAT TGGTGGGAGCTTGGAGAATGCTTACTTGTTATTCCACCAAATGGAAAAGGAAATCAGAAG TGTACATAGAGCTTGTGTCCACTCCCTTTCCATGTGTAAACTGGAGTAGAGGCAGTGGCA GGTACGGGTGCTTCCTTGTCCATGGTGGAGCGTGGGTGAGAGACATGACTGACATTCTGC CATCTCTATGGAAGGTTGGTCAGCTGCTGCCTCACATCAGCATGTTGTCAGGATCTTGCA TCAGTATTGAGCACCAGCCATTCCCTGACCAGACTCTATGTGGGGGAGAATGCCTTGGGA GACTCAGGAGTCGCAATTTTATGTGAAAAAGCCAAGAATCCACAGTGTAACCTGCAGAAA CTGGGGTAAGTCTTCATGGGTGTCTTACCAGAAAAGTAACTTCTTTTCAGAGGTGAATTA TTTGGAAAATGTGGATGGGGGTTACTTTGGTCAGGCAGAGCTGAAGGTAGAGTAAGGAGG TAAAAACATCAGAAATGCTTTGAAGGACTGGAGGCATATAATGTATACTGCTGCTAATAA GATAATTTATGCTAATTTATGATTATAGAACTAGAGTTTCTTAGTGTTGGAAGAAACCTT AGAGATGGTGCAGCCCAATTGCCTGTTGAGGGAAAAACTTGCTTCCAAGACACTCACATG AATAGTCACCCATTTTATGTGTGCATGCTTGCAAGCATGCAAGTTATCGCATAGTGCATG CAGCCTCTACACTAGGAAAGAGCTCTCACCCTGCAGCCTCTACACTAGGAGAGGACTCTT ACACTGCAGCCTCTATATCCTCAACAGTGTCATGGCTCAGCACCTTCACCTATGTAGCCA TGCTCTCCCAGGTACACAGGCTGGTTTGTTAGTGTCTGTCTTTGAAATGTGGTGCCCAGA CCTGATGATGCATGGTGGATGTTTTACCTCCTGTTGCAGAGAACTATGGTTTCACTGGTG GAATCTCTGATTTCCTTGTTTTTTTTGGCAGTTACATAAGCCTTTTGATTCATGTTGGAA TTCTGCAGTAAACAGTAGTAGGGAATACCCACTAATAATCATGCACTTTCCCTGTACCAC TTTCCTGTATCACTTTCCCTGTATCACCTGCTCTTTCATGTTCTTACATGGATTTTCTCA GTTGGCTTCAGAAAGATGCTATAGGGTAGGGTATCTGTGTCTCCAATTTAAAGAGGAGAA AATAAAATTCAGGGAGCCTCATAACTTTGTCCAAGGACACTCAGAGAGAAGGTAGTGGAA CTCAGTGTAGACAAACGTCTGTGACCTCCCAAGCCACTGCCTTAATTCCCAGTGCATTGC CTTAGGAGATGTTGCTAATGGGCTCTCTACAGGGCTTCTTCATCTGGCTCTCAGCTTAAG GGTGGGACCTCCAATTTAGCTTTGCTAAACCTCATCTTACCTGTCTTTTGACCCATTGAC TAGGCAGTTTTGAATCTTCATTCTGACAATAATATCTACAAATACAATAAGCAAATTGGA TAGGTCTTCATTCATTCACATTATTAATATATATACCAGCCAGATCAGCATTCAAGACAA AATTTGGCAGGAAAGGTCTTCCCAGAGGAGTAATCCACTAATCCATAATTAACAACCAAC CTCTGTTCACAAAGCTCTGATACTTCCTTGGACCTCTCCCATCAGCCAATCCTCAGATGT GACCATATCTCTTTCTATGAAGTCTTCCTGCAGTGCCTTCATTTCCTCGCCTTAGGGTAT TACCCTTCCTTAGCAAATCGCCTTAGAATATTACTCTTCCTTGGCAATTTGACTTCTGCT TCTCTAAGTTTGTTCAACAGACATGATTTTGTCCCTTCATTTTGCAGGCCCTCTGGGGGC TCTGTGGTGGGCACTGACAGCAGCAGTGAGTAAAACAGACCAAAATCCTGTTTTCACAAC CGTTCTTTTAGGGAAGTGATAACAGATAATAGACATGCTAAACAATATACCCTGTGTATA AGAGCTATAAGAAAAACTGGAGTGACGGCGAGGGGTGCTTCTCTGCTCACGTTTGGCGAG TGCCTCTCCGAGCGGGTGACATTGGAGCAGGTGCTCAGTGAAGCGTGGGATGGGCTGTGA AGGAGCCGGAAGAGCCCTCCAGGCAAAGCAGATGGAACCGAAGAGGCCCAGGCGTAGGCA CTCAGGTGACTCTCAGTGATCCTGGTTCCAAATTCCACATGACAAACAAGCCAATTACAA ATGTGCCTGATGCATCTGTAATATGCTCTATGTAGTTACTATTGTCAATACCTAACCTGG TAGAGCTGCTGTAATAAAGTATCACAAACAGAGCGGCCTAAACAACAAGAGTTTATTGCC TCTCAGTTCAGGAGGCCAAAGTCTGAGACTGAGGCATCAGCAGGCTGGGTCCTTATAGGT CGTACAGGTCCTTCCCAGTCCTTACTTTAGTTGACATCTGCTGCCTTTAATTCATTTCAC TCTTCCTCTTTGGAAGCCTTCTTCGCTCTTATTTTTAGGTCACTACTTAGTCTTTCCTGC TAATGTTATAGCTTCCCCCTCCCTGGATCCTGCATTGGCTTCTCTTCCTGTGGTCTGGGG ATTTCACGACTGGTTTAGTTGTGTTTTTTTTTTTTTTTTTTTTTTTGAGTTGGAGTCTTA CTCTGTCACCCAGGCTAAAATGCAGTGGCGCAATCTTGGCTCACTGCAACCTCTGCCTCC CGGGTTCCAACAATTCTTCTGCCTCAGCCTTCTGAGTAGCAGGGACTACAGGTGTGCACT GCCATGCCTGGCTAATTTTTGTATTTTTAGTAGATACGGGGTTTCACCATGTTTGCCAGG CTGGTCTCGAATTTCTGACCTCAGGTGATCTGCCTGCCTTGGCCTCCCAAAGTGTTGGGA TTACAGGCGTGAGCCACACACCCGCCTGGTTTACCTTTTTTGTTGTTGTTGTTACTAAAT ATTTCTAAACTCCCTGAGAATTCTCATATACCTCTCAATTTCAACAACAGTAGGTCTCAA ACCCAGATATCATTCACAAACTTTTTATTAGAAAAGTAACACATGCTTGGTGTAAACATA TCATAGTACAGACAAAGTGGAAAGTGAAAGCTCCTTCTCAGCCCTCTTCTGAGAGAGCCA TTTACAATAGTCTGATGAACAACCATCCAGACTTTTTTTAATACAATAGATTGTTATATA ATCCATTCATCTGTCCATCCATCCATCCATCCATCATCCATCCCTCTATTTTCCATCCGT CAATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCAATCCATCCAAGGGA GTATCAGAGCTTTGTGAACATATATTGGTTGCTAATTATGGACAAATGGATTTCCTGTAT ATGCTGATCTGGGTGGTATTTATATCAGTAATGTGAATGAAGACCTATGTGATTTTCATG TTGCATTTGTAATACATTGTTATGTAGTATTTTAAATGCCTAGTCTGTTAGAGCTACTGT AATAAAGTATCACAAACAGAGCAGCTTAAACAACAGAAATTTATTGTCCCTCAGTTCTGG AGGCCAGAAGTGTGAGATTAAGATGCTAGCAGGCTGGGTCCTTCTGAGGGCTGTGGGGAA TCTGTTCATGCTTCTCTTTGGCTTCTGGTGGAATGTCATCTTGCTGACACATTTTGCCAT TCCTTGACCTGTAGATGCCTCTGCCACACCATTGCCTTTATCTCTACGTGGTGTCTTCCC TGTGTCTGTGTGTGTCTTTCTCCATGTCCCAAGTTTCCCTGTGAAAGAACACAAGTCATG TTAGATTTGTAACGACCTGATCTTAACTAATTACATTTTCAGTAACCGTATCACCAAATA AGGTCACAATCTGAAGTACTGGGGCCTAGGACTTCCACATATAAAGTCTTAGAGGAAACA ATTCAATCCATAACACCCTATCTATTGAAACTAGAACCATAATATAAATATTTTTCTGTG ATATCCTTTTTTCATTTATCATGGATAAATTTCCATGCTGATTTGTGTAGATCTATCGAT TGGGGCATAATATCCCATAGTGTGCTTTACCATAATTTATTTAATCAAATCATGCATTTT GGGATAACTGTTCTTTTCCACTATTACAAACAACTCTGCAAAAAGCACATTTGTATATAT AGTTTTATGCATGTGTATTTGCTTTGAGATAGGTATCTATAAGTGGCATTAATCAGTCGA GACTTTTATGCATTTTATGTGTTAGGTACAGCCATACATGTGGCTGTGTGTTAGGTATAG CCTATGGGTTAGGCATAGCCTGTGTGTTAGGTATAGCCTATGGGTTAGGTATAGCCTACG TGTTAGGTATAGCCTATGTGTTAGGTATAGCCTATGTGTTAGGTATAGCTACATTTTTTT CTCTCGAACTTTGGGTCCTCATCTCTGGCTGCATATTGTGTACTGCCTGTCTCAATACTG CTCAAGGGTCACACATGCTGAGCATTTGCAACATTGGTTTAATTATCATACCCCACCTTC CACCCCCGTTCTCTGACCTGCTCCTGCCCTCTTCCTCCTGCCTCATTGAATAGTGGGGCT TTCCAGGAGGCTGCTGAGTGAGTAAACGGGGGACGGTCCTAAATGCTCTGCTTTCGGTTC CCTCTACCACTCATCACTACACCAGAGGGAACTTTTTAAGATGCAAATTTGAAAATATTG ACCCTTTGTTCAAAAATCTTCAAAAGTTCTTCTCTGCAGTCAGAGTGACATCTTAGCTTG GCACACAAGGCTGTCCCTGATACTGCCCTCTCTCCTGCCATACCTTGCACTCCATTTTGA GTCATATTGGATGAGTTTTGTTTTGCTGTTTTAGAGATGGGGACTTGCTATGATGCTCAG GCTGAATTTGAATTCCTGGGTTCATCTACAGCCATACCACCCAGAGTGCCTGATCTCATC TGCACTCCTGGGCTCAAGCAATCCTCCCGTCTCAGCCGCCCAAGTAGCTGGGACTATAGG TGGACATCACTGTGCCCAGCTATGAATTAGTTTTGAAACATCTTGGTGGTTCTTTTAATC TTCCTTATTCTTGCTACTCTTTTCCTTTTGCCTGGAAGGTTACCCCCACTTTCCCACTTT CTACTATCCATCTAAGAAGCTCCTACTTATTTTTTAATTACTGTGATCCTCATTTTGTCC ATTTAAAAGCAGGGATAAAACTAACATTCCCATCTTGAGGTTGTGATCATTCAATGAGAT AACCCTGTTTAAAGTCGTCATCCATGTCAAGCACACAATAAATACTCAAAAAATGTTTGA TCTTCTTCTTCAGATTCCTTCCTTCCTTCCTTCCTTCTTCCTCCTCCTCCTTTCTTTCTC TCTTTTTCTTTTTCTCTTTCTTTCTTTCTTTCTCTCTCTCTCTCTTTCTTTCTTTCTCTT TCTCCCTTCCCTTCCCCTCCCCCCCCCCTTTCCCTTTCCCCTTTCCTTTCCTTATTTTCC TTTCTTTTCTTTTCTTTTTTTAAGACAGGGTTTTGCTCTGTGGCTCAGACTGGAGTGCAG TGGTAGGATCATAGCTCACTGTAGCCTTGAACTCTCCTGGGCTCAAGCAATCTTCCTGCC TCAGCCTTCTGACTAGCTAGGACTACAGGTGTGTACTACCATGCCTGGGTAATGTTTAAA ATGTTTAAAATTTTTTATGTAGAGACAGGGTCTTGCTATGTTGCCCAGGCTGGTCTCAAA CTCCTGGCCTCAAGTGGTCCTCCCACCTTGGCCTCCCAAAGCACTGGGATTCAGTTTTCA TTATGAGACAGTTTTGTGACATAGGCAGGTAGTTAATAAATAAAAATCCCCAACCAATTA ACTTAATACAGTACATGGCAAGATATCCGTGCTTGGTAAATGTAGAGCTCAGTTAGGTGG ATTGGTTGAAATCGAGATGTCAATCACATTCCTCTAATCCAAGGATTGGTTGGTGGGACA TGGTTGTTTGATTCTTTAAACATTTTATTATGTGTTCAGTGTAACCGTTGCTTAATAGTT ACCAGCATTTTCACAATTTGGATATGACGTTTTCTTAACAAAACTGCACCGTCTGTTGCA ATTTCTACTACTACTGTGTAGTGCTCCCCAAACATCTGTTGAATAATCCATTCTACTCCT TTTTGGAAATAGTGGTAAAGCCTGCATAACTTTAATTACATAATTTAAAAAATATTTTCT CTTTTCCTCTTTGAAGACCATCCCCATTCTACTAGAATGTCCCTGGCCTTTGCCAGGAAT GCTACTAATCCCTTCTGCATGTTAATTAACAACAACCCTCTGATAGAATTCTTACCGGGG ATGAGAGCTTAGTAGAAGCCACTCAAAACTTGCTTTGTTTTTGTCTGTCTCTCTTGGGCT TCATTTGCCTATTAGTCTTACTTACTGTGTCTTTTCAGTTTGACTCTTCCTTAATTGGGA AGATAGAAACCAGTGGATGGATAATCACTTTTTCCTGCTGGTCATCTGTTCATGCTTTAC TGTCTGAATACACTTTTTCTGTATTTCTATTTTTCCTGCCTCGTAGACACCAAAGAGCTT AAAAAACATGCCATTGCCAAGGACTCTGGCAGGAAGGAGGCAATCACCTGCGCTATTCCT GGCTTCATGGAATAGAAGCATCTGTGCTCCTAGGAATTACGCCACCAGTGATTTTAGAGC TCTTATGCTCTTCCTGGGTGATAGAATGGGCTTAATTTGACTCAAGAATAGTACATCAAA ACTCTTAATTCCATCGAGATTGATGCATTTTTGGGGTTTTATGCTCTAAAAGGCCTTTTG CTGTGCAGAAGGAAGAGAGAGGTGGACAGAAAGGGCAGTGGGGAGAAGATGAGACTAAAA GGTGGAAAGTCCAGGTCTGGATCCCTCCCCACCACACACCTGCTCTGTGGCCTTGAGAGA AACATGTAATTTTTATAAGCCTTAGATTTCTAATATGTAAAATGTATGTAATAGTTTTAG CTGCACTCCTTCCTTGCCAGGTTGATATAATAATCAAATAAGACTGGTCTCTGGGTCAGG CACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATTGTCTG AGCCCAGGAGTTTAAGACTGCAGTGAGCTGTGCACTTGGCCTGGGTGACTGAGCAAGAGC CTGGCTTTTTCTATTTATTTATTTATTTTTGAGACAGAGTCTCACTTTGTTGCCCAGGTT GAAGTGCAGTGGCAATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCAATTCTC CTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCACCCTAACTAATTTT TATATTTTTAGTAGAGATGGGCTTTCACCATGTTGGCCAGGCTGGTTTTGAACTCCTGAC CTCGTGATCCACCCTCCCAAAGTGCTGGACCTCCCAAAGTGCTGGGATTACAGGCATAAG CCACTGCACCTGGCCTTATTTATTTATTTATTTAGGCAGGGTCTCACTCTGTCACCCAGG CTAGAGTGTGGCAGCGCAATCATGGCTCACTGCAGCCTCGACTTCCTGGACTCAAGCGAT CCTCCCACCTCTCCAACGTGGTTGAGGGCTGCAGCGAGAAAGATGTGAAAGGGGCATTTG GGGGCGCAGGAAGGCGGGAGGTGGCAATTGCTAAGGGCCCCGCCGTGTTCCTGTCACAGC CCTAGCTACAGCTTAGAAGGTCACAATGGACGTTCACCTGTTGTCTTTGATGTTTAAATC AGCACCGACTTCCCATGAGGAGGATTTTTTTTTCCTGTCTCTCTTAAAAAAAAAAAAAAA GGCCCCTGCAGTGTGGGTGTCTGCAGTGTTACGGGGATTATTAGTTGAGGATAACCACTG GGATGTGTTTCTGGAAGAAGTGGTGCTGAGGAGCACTCCTGGCCGGAGGAAAGCTGTGTG AGGAGGAGGAGGAGTATGGGGTAACTGGCTCAGTTTGCCTTGGCTCTTTCTGTCGGACTC ATACAGCAAAGCATCTGCTGAGACATCATTTGTGTCTCCTGTGACAGCCAGAGACAGCAG GTCTTGCTCTCCCCAGATCATATCTGAGATGCTGGCTCCTGCTCTCTGAGCTGAAGGCTG CAGCTGCTGAGAGAGGACGAGGCACTGAGTCAAAGCAGCTGCACAATGTTGGGGAACAGC TGGGTACTGAGGACTCTTCTCCCTGTCCTTCTACAGGTTGGTGAATTCTGGCCTTACGTC AGTCTGTTGTTCAGCTTTGTCCTCGGTACTCAGCACTAATCAGAATCTCACGCACCTTTA CCTGCGAGGCAACACTCTCGGAGACAAGGGGATCAAACTACTCTGTGAGGGACTCTTGCA CCCCGACTGCAAGCTTCAGGTGTTGGAGTAAGTCCTTTGGTTTATTACAGCAATGAGAAC ACATGGTGGCCAAGGGTGGAGGGACGTTTAGGCAGAGTGGCCACAAGATAATCTGTATCT TAGAAGTGAGGTGTCTTCTTAGTGTTTGCCTTGTTACAGGATCATGGGACTGGGAGGAGT CCTTCCAGATGATATAGATGTAGGAACTTGAGTCCTTACCATCACAGTTTTCTGTACCAC AAAACAAGGAGGGCAGTATGACACTTACATTTTATGGAAATGTAGGGAAAGGCACAGAAT TTGGTAAATCAATGAACAAACCACTGTTACTAATTTGATCTGTGCAATGCAGTGGATTTG AAAAAGAGAGAGAAGAATAATTACCAGCATACAAGGCTGCTTGAAGCTAGTTAGTCCTGT GCTCCTGTGCTTTTTTTTTTTCCACCTGAAACAAGACAGGCTAAGATGCTAAAATCTTGG GGAGCTAGGGGGATGGTTAAGGGGACATTTTCTTTAAATCACCCCCTTTTTGCAGATTAG ACAACTGCAACCTCACGTCACACTGCTGCTGGGATCTTTCCACACTTCTGACCTCCAGCC AGAGCCTGCGAAAGCTGAGCCTGGGCAACAATGACCTGGGCGACCTGGGGGTCATGATGT TCTGTGAAGTGCTGAAACAGCAGAGCTGCCTCCTGCAGAACCTGGGGTGAGTGTGCTCTG CAGAGATGCCCGTGGTGGGACTCTGAGTTCTCAGGAAACGTTGACTGTTATCAAAATCCA GGATGGCTCTCGCTTCATTTGCAGCCACTCAAGATTAGGTTGGGCCTGGGTCAGTTGTGG TGGATATTTTAAAATAGAGAATATGGGGTTAAACTACACATTCCACTTCACTGAGATGGT TAGAATCACCAAGGCTAAGCTGGATTTCACCCACATTCCCCAAAGAAACACAAGCCCTCA TGCGATCATGGCCAAGGAGGATTCTGTTCTACACAAGGAACCGAACTTCGTAGAACTCGT CTATGGGTCATCCAAATTGGAAGGGTCTTTACATAGTGGGGATCTTGTTGTTTTGTTTCT GAGGATTTATTTTTTTTTTCCTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGC AGTGGCATGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCC TCGGCCTCCCAAGTAGCTGGGACCACAGGCGCCTGCCACCACACCCGGCTAATTTTTTGT ATTTTTAGTAGAGTTGGGGTTTCACTGTGTTAGCCAGGATGGTCTCCATCTCCTGACCTC GTGATCTGCCTGCCTCGGCCTCCCCAAGTGCTGGGATTACAGGTGTGAGCCTCCGTGCCT GGCGGTTTCTGAGGATTTCTAAATGGGAAAAGAGTGCTCCAGGAATAGCAAGATGGGAAA TTACACGAAATTCGACAGTGTGTCAGGATATTGCCAGCCCACCTCTGTGATACTACTGAG GTAGTCGTCTCCTCTCTAGCAAGAGCTTCCTGGCGAGTCCCACGGTTCTGTCAGCCGTGA TGATTGCACTTTTCCCTGAAGACGTTTTCACTGCTTGGCTTTAAGGCCAACATGCTCTCC TGGGTTTTCTCCTATTTCATCAGATCCTTCTACTCAGTCTCCTTTCTGGCCTCTTCTTCA TCATCCTGACCCTTATGTGTTGAATCCTCAGAGCTTAGTCGCTGGGCTAATTTTTCTTCC CTACACTTTCTCCCTCATTTAAATTATCTGGTCTTCTGGCTTCATGATATGTGTGCTGTG GCCTCCAGATTATATGTCCATAAATTCTGTGTCTCCGTGCTTGGCTGATCTTTCTTCTTG AAGGTTTAATAAACCTCTCAAACGTCACATCTAGATCCACACCCTTGCTACTCTCTTCTA CCCGAAACCTGATTCTTCCCCATTTCAGTCGATGGTCACTTCCTCCAAGTTGCTCGGGCC AAAACATTTCTGGTTCTGTCGTCACTGTCTCTTTTTCCTTATAATCATGTCCAATGTGTC AGCACATCCTGTGAGCTCTGCCTTCCCAGCTTGGCCACTCCCTGACCACTTCAGGCCAGC TTCACGGCTTCTTCCTTGGCTCAAGCCACCATCACCTGGTGTCTGGATTGTCATGGTGGC ATTCTGACAGGTCACCCTGCATCTGTTATTCTGATTTTAGCAGACAAGGGATTCAGCTAA AACGTAACTCGCATCATATCACTCTTGTCAACATCGTCTTCTTATCACTTTCATAATCAG AGCAACAAACTCATGGTGGCTTCCATGCCCCACATAATCCAGCCTCTCCTGCTTCCGAAG ATTCCGCTTCTCCCAACCCTTGCTTATTCTGCCCCAGTACAGTGATCTCCTTGCTGTTTT GCAAGAACACTGTCATCTCTGGATTTTTGCACTTGCTTTTCTTCTGGCCTAGAACTCTCT CCCCTTCAGTATCCACCTGCATTATTCCCTGTACCTTCCTAAATTCTCTGCTTAAAGGTC TTCTCTGCGAGGCTGTCTTTGACTATTCTACTGAAAATAGAAGCACTTTTTCTTCTCTTC TCATTCTCCTCTGCAGTGTAGCACATCTTATGTGCTATGTCATTTTCTTGTTTATTTATT ATCTATCTCTGCTCCCAAAATATAAATTCCATTAGTCCAGGGACTTCTGTCCATATTAAT GATCTCAAGGCTGAGAACTTGTTGGAATGCAGGTTTGAATAAATACAAGTTTGAATCAGC CTTGCATCCTTGTGCCAACATAATGGAGCACATTTGCTGCAGGACAAGCCAATATTCCCA GAGCTAAGAGAGATGGGGGAACAAACAAAGGATTGGTCAGGTCAAAGCTGGGGACACTGC TACATGTAGCATCACTGACCTAGCCCTGAGGGACATTCTGGACCCAGGCTGAGGGACAGG CTCAAAATAGATTGAAGAATCCATGAATGCAATCAACCCGTTTTCTCAGGCTGCGATAAC AAGCTGCTTTAGACTGTGTGACTCAAACACAGATTTATTATCTCACAATACTGGAGGCTA GAAAGTCCAAAATCAAGTCTCTGATGAATTTGGTTGCTGGCGAGAGTCCTCTTCCTGATT TGCAGATGGCTACCTTCTTGTTATGTGATTGCATGGAGGGAGGGGAGGCAAGGGAGAGAA GACAGGGGAGAAAGAACAAACTCTCTGATATCTCTCCTGTAAGGGCACTCACCCCATACT GAGGGCCCCACCCTCACAACTTCATCTAACTCTAACTACTTCCCAAGGGCCTCACCTTTA AGTACCGTACATTAGGGGTTCGGGCTTCATCATGGGAATTGTTAAGGAAGACAAACATTC AGTATATAACACCACCAAATTGAGATGGTTATAAATGGTGCAGGACAAATGGGTGGATTT ATTAGTTAAGTTGCAAGGGAAACTTTATTAAAGAGGAGGAAGAACTTACATCGAAGATGT GAGAGGCATCCTGGGCAAATGCAATGTGTAGAATTGATCAGGTTAGTGACTAAATGAACA TAAGGTAAAAAAATTTACAAGACAGTTGAGGAAGCGTAAATGCTGACTGGACATACAGTG ATACTAAGAAATTATTGTTAAACGATTTTGGTGTGATAGTGACATTGTAATTATATTTTA GTGTCACAAAGTGAATTATTGATAGATGCATTAAATGCAGTATTTAAAATAATCCATGGG TGGGAGGAGTGGGTGGGCAATAGAAGAAACAAGTTGACATGACCTGTTTAATTGTCGAAC TTGGGTAATGGACACAGGGGGTTCATTATACTATTTTCTATACTTTTATGTATGCTTAAC ATTTTCCCAACTAGATAGTTAAAAATATAACAGGAACCACATTGGGCACTTAGAGCTTTT TTTTTTTTTTCCCCACATTTTTATTGGGAGCCGTGGGAGGGGCCTCCTCTGTCATTGGAG GTGCTCACAGTTTCTTCAGCCACTCCAGGCTGGGGTCCTGGGGGTCTGAGGCTCCCAGTG ACGAAGGACACGACGAGCACCGGCTCCTTGGCCCAGGCATTCTTGAAGAAGGTGCGGAGT CTCGCGGCCATCTTGGTCTCGGCGGCGGCGACGGCGGCGAGGACGCGGAGCACTCTGGGA GTTGTGGTCCCTCTTTTTTTTTTTTTTTTTTTTTTACATTTTAGAAGTGTGTGGAGTTTA GGGAAATGAAGAGATGAGACTTTTAAGGTTAACGACTCTGACAGAGTTATCTGAAGAGTG CAACCCAGGCTTTCTATTTGCTTTTACAGGTTGTCTGAAATGTATTTCAATTATGAGACA AAAAGTGCGTTAGAAACACTTCAAGAAGAAAAGCCTGAGCTGACCGTCGTCTTTGAGCCT TCTTGGTAGGAGTGGAAACGGGGCTGCCAGACGCCAGTGTTCTCCGGTCCCTCCAGCTGG GGGCCCTCAGGTGGAGAGAGCTGCGATCCATCCAGGCCAAGACCACAGCTCTGTGATCCT TCCGGTGGAGTGTCGGAGAAGAGAGCTTGCCGACGATGCCTTCCTGTGCAGAGCTTGGGC ATCTCCTTTACGCCAGGGTGAGGAAGACACCAGGACAATGACAGCATCGGGTGTTGTTGT CATCACAGCGCCTCAGTTAGAGGATGTTCCTCTTGGTGACCTCATGTAATTAGCTCATTC AATAAAGCACTTTCTTTATTTTTCTCTTCTCTGTCTAACTTTCTTTTTCCTATCTTTTTT CTTCTTTGTTCTGTTTACTTTTGCTCATATCATCATTCCCGCTATCTTTCTATTAACTGA CCATAACACAGAACTAGTTGACTATATATTATGTTGAAATTTTATGGCAGCTATTTATTT ATTTAAATTTTTTGTAACAGTTTTGTTTTCTAATAAGAAAAATCCATGCTTTTTGTAGCT GGTTGAAAATTCAGGAATATGTAAAACTTTTTGGTATTTAATTAAATTGATTCCTTTTCT TAATTTTAAAAAA OMIM ID 606416