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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CISH (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1154 Official gene symbol CISH Full name cytokine inducible SH2-containing protein Aliases ,CIS,CIS-1,G18,SOCS, Gene summary The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 3   Locus: 3p21.3 Gene position 50649262 - 50643885  Map Viewer Gene orientation minus Gene size 5378 bp Gene sequence >CISH:complement(50583885..50589262):Length=5378 CCCGCTCGTCTGGCCCGCCCCCCTCGCCCTCGCAGGCGGTCCGCGCCACTGCCTCTCAGT CCCTGTCCTGCGCCCGCGCGCCCCGGGAGCCTACCCAGCACGCGCTCCGCGCCCACTGGT TCCCTCCAGCCGCCGCCGTCCAGCCGAGTCCCCACTCCGGAGTCGCCGCTGCCGCGGGGA CATGGTCCTCTGCGTTCAGGGGTAAGCGCGGCTCTCTGCCCCCTTCCCGGCCACCACGAG GGGCGCACGGGAGAACAGGGGCTTCGTGCTAGCTGCCGGGCATTGGGAGGGCTTGACGGG CCAGAGGTGACTGAGCGCAGACGGACCTCAGGAGCAAGGCTCTGTGTGGGGCTGTGACAC TCCCACTCCCCGCCCCCACACACTTACCTCAATTCCCACTGTGGATTGGGAAACCGGGGG CTGGCCGGCTAAAGGAGGAACTCACAGGGTGGGCTCAGCCTGGGTTCTCATTGGAGCAGA TGGATGCTAACGGCACGGCGTCCCCCAAGATGTGGCCAACAATCCCAGATATTCTTCTGG GCCCAGAGCACTCTACGCTAGCCTGCCTGCTGCCCTGCCTGCTAGTAACCTTGGACCAGC CCCTGGCCCCCTCTGTCCTGGTGTCCCCTCTCCTGCCCCAGGCTAGCAAGTAGGCTCTTC TTGGGAAGCCAGCCGCAGATCCTTGCCTTTCCTCAGGCTGGCACCTGATGGTCTGCAACT CTCGGGAGGCCCTGGGTTTGGCCTGGTCCTGCTTGGGGTACCCCCACAATCGTCTCACAA CCCTGTCTCAGCCCAGTCTGGGATCCCAATGTGAGAAGGACCTTGGCTCCTGCCTCTCAT CTTCAAATTTCCCAGACTTGAGGTAAGGGACAGTGGAGAGGGGATGCTGATAAGACAGAG TCTTGACCTGAGCTGAGCATTCCTGGCCATCCACTCTGTCCTGAACCTCAGCAACCCCTT CAACCAAAGGGTCTGATGCTGGCCATGGTGATGTGACAGGAGCTCAGGAAGCTCCAAGGA GAGAGGAAGAAGGTATAAATGGGTGTTCTGCACTCAGGGAGGACTGGGTGGCTGTGCTTA TCGCAACTGGCCTGGTGCCAAGTGAGGGAGGGTGGAAGGTGAGGCCAAGGAAGAGGACAT GGAGGTGCTGGGAAGACTACTTCTCCCTTGCTGTCTCCAGCAAGTTCCTTCCTCCTGTCT GCATTCTGGGACTCCTGAATACCTGCCCCACCACTGCCTTCCACCCCAGGAGCCTCCCCC TGCATTCCGGGGTCCCATAGCCTCTTTCACTTTTTACCCTAGGTGAGCACCCCCTTGTAA GCTCAGGGCTACTGTTGGGTGTCAGGGAACAAAGTTTTAGACTGCTGCGCTCCAAAGCGG GCACACACATGTACCTAGAACACACCAGCCACTGTCCCCACCATGATGATGACACAGCCA TGGACACACCCCTGCCCAGGTACACACTCACCAGGAGCTTGTGGTGATCAACACAGCTAT TCATACACCCAGCTACCACATCAGCCCCAAAGGTGCCCACACCTACATGTGGGATCTGAG GACCGGCTAAGCTATCTGGACGTGGCCACCCACAGAGGTTCCAGCCTGACTGGCTAGCCA CCAACCATGCTCCTGGGAAGGTAGCTCTGGGCCCCAGCAAGCAGGTCATCTCAAAATTTG GCCTCCAGCTCTCCAAGAGGGATTTCCAAGATCCCACAGTACAGCCAGGGTAGGTGTGGA AAAGTTTTTGTCAGGCTGTGGTGTGCCAGAGTTGTGTGGCCCTTTCTCACTGTGAGTGGT CATAGGGCCATGATTTGTTAGAACCTAGAGGGTCACCTATAACCTACACAGGAGTCAGGT CTGGCTCCTGCCACCAGCTCCTGCCTGCGCCTTCCTGCCTCACAAGCAATACTGGCGCTG TTTGCCCATGCTGTCCTCTCTACCTGGGGTCCCTTCCCCCAGCTCCTTCCTTTGGCCTGG AAGACACAGCTCAGGAGCAAGCAGACCCTGACTCCCCCGTGACACCTGCAGTTTTATGAC TTTGCATTATAATTACTCTTAGTGTCATCTTCCCCAGCCAGTCTGGTTCTCCTTGAGGGC AAGGCCATGGTTTCATTATGGCGGTGTCCTGAGGCCCAGCCAGGGACTAGACCCAGAACT AAGGCTTGGAGATGTATTTTGCAAGGAGTGAGGGAGGAGCAGCTGTCTTCCTGGGGAAGT AGAGCCAGTCCCTGCTGCCCTCCCAAGGAGGAAGCCCTAGTATCACCCTGCTGGGTGGGC TTCCCCTAGGAGAAAGCTGCTACTCAGATTTTGGTCGGCTCAGTTCCCCCAACCCCAGCC ATCCAAGAATATGGTGTTACTGAACCTCTCAGTGCATGGGTTGGTGGGACCCTTTATTGC GGAAAAGGGAAACTGAAGCCCAGTGAAGAGCAAGCTTTGTACAAGATCGTAGAGCCTGGT AGGGCTGGCTTGCCAGGGTGGGAACTGGAGTGTGGATTAGGTCCCTGCCCTTGGTGGGAG CTCATACTGACAGGAGGTGAGACTTGCCAGTGCCTTTAGAGGCCACTGTCCACCCCAGAC CCTCCACTGGGAGAAGCAGAGGCCAGGATAGGCTGACTTGTATGGGTAGGGGATTATTTC AGTCTCTAAGTCCTGGCCAGTGTGGACCTAGGTCCCTCTGAGAGACACTCCTATCCATGG GGAGGTAGCGTGTGACCTCAGGCAGCCTACCATAATCCTGGGGCTTCTCTGGAGGACCCC ACACAGATCTATCATAGGATAAATCTACTTGTCTGTCGTAGATCTATCTCAACTAGGACC ATTCATCAGTGGGCCATTTAATCAGCCCACTTCAGCCAGGAGGGCACAAACATGAAGCTA CTTTGCACTGAATCCTATCAGTGTGGTGAGAACATTAGACATGCCTATAGGGAATGATCT GTGTTTTTGGTTGATATAAAATAGAGAGCAATTAATTACTGTTTAGTAAATGCAGGGCAG TGGAAAAGAATCTTTCAAAAGAGGATCCCCACATGGAAACAATCAAGGTGGCTTTTGTGA TGACAAGTGGGGAACGAGATACTGGACTAACTGAGCCCATGGCTGGGTAGAGGGGAAGCT GAGGCTCATAGTGAGATGGGCCAGCCAGAGGTCATGAAACTAGTCTGGGGCATAGGGGGG TCTCTGGAGATGGGGGAAGCATGGGTCCTCCACTCACTGCTCATCCACTGCCTTCTAGAC CTCGTCCTTTGCTGGCTGTGGAGCGGACTGGGCAGCGGCCCCTGTGGGCCCCGTCCCTGG AACTGCCCAAGCCAGTCATGCAGCCCTTGCCTGCTGGGGCCTTCCTCGAGGAGGTGGCAG AGGGTACCCCAGCCCAGACAGAGAGTGAGCCAAAGGTGCTGGACCCAGAGGAGGATCTGC TGTGCATAGCCAAGACCTTCTCCTACCTTCGGGAATCTGGTGAGTCTGAGGGGGGAGGCA GGCCTTTTCCTGAGTAGTCTGGTGGGAGAAGCTTAGTTCTGCCTTTGAGTCTGATTTGGG AGGCATAGCCCGGCCCAGGAGAGTCTGATGGGAGAGGCACAGCCCTCTCTAGGGAAGCGT GAAGCTGGAGGCACTGCCTTGACTTGCACTGGATTGGTTACCCCAGCTAATTTCCACTAT GTCCCTTGGCCCCCTCTGCACTTGCCTAGGCTGGTATTGGGGTTCCATTACGGCCAGCGA GGCCCGACAACACCTGCAGAAGATGCCAGAAGGCACGTTCTTAGTACGTGACAGCACGCA CCCCAGCTACCTGTTCACGCTGTCAGTGAAAACCACTCGTGGCCCCACCAATGTACGCAT TGAGTATGCCGACTCCAGCTTCCGTCTGGACTCCAACTGCTTGTCCAGGCCACGCATCCT GGCCTTTCCGGATGTGGTCAGCCTTGTGCAGCACTATGTGGCCTCCTGCACTGCTGATAC CCGAAGCGACAGCCCCGATCCTGCTCCCACCCCGGCCCTGCCTATGCCTAAGGAGGATGC GCCTAGTGACCCAGCACTGCCTGCTCCTCCACCAGCCACTGCTGTACACCTAAAACTGGT GCAGCCCTTTGTACGCAGAAGCAGTGCCCGCAGCCTGCAACACCTGTGCCGCCTTGTCAT CAACCGTCTGGTGGCCGACGTGGACTGCCTGCCACTGCCCCGGCGCATGGCCGACTACCT CCGACAGTACCCCTTCCAGCTCTGACTGTACGGGGCAATCTGCCCACCCTCACCCAGTCG CACCCTGGAGGGGACATCAGCCCCAGCTGGACTTGGGCCCCCACTGTCCCTCCTCCAGGC ATCCTGGTGCCTGCATACCTCTGGCAGCTGGCCCAGGAAGAGCCAGCAAGAGCAAGGCAT GGGAGAGGGGAGGTGTCACACAACTTGGAGGTAAATGCCCCCAGGCCGCATGTGGCTTCA TTATACTGAGCCATGTGTCAGAGGATGGGGAGACAGGCAGGACCTTGTCTCACCTGTGGG CTGGGCCCAGACCTCCACTCGCTTGCCTGCCCTGGCCACCTGAACTGTATGGGCACTCTC AGCCCTGGTTTTTCAATCCCCAGGGTCGGGTAGGACCCCTACTGGCAGCCAGCCTCTGTT TCTGGGAGGATGACATGCAGAGGAACTGAGATCGACAGTGACTAGTGACCCCTTGTTGAG GGGTAAGCCAGGCTAGGGGACTGCACAATTATACACTATTTATTTATTTATTCTCCTTGG GGTTGGTGTCAGGGGCGAGCCAACCCCACCTCTATGCCCTGAGCCCTGGTAGTCCAGAGA CCCCAACTCTGCCCTGGCTTCTCTGGTTCTTCCCTGTGGAAAGCCCATCCTGAGACATCT TGCTGGAACCAAGGCAATCCTGGATGTCCTGGTACTGACCCACCCGTCTGTGAATGTGTC CACTCTCTTCTGCCCCCAGCCATATTTGGGGAGGATGGACAACTACAATAGGTAAGAAAA TGCAGCCGGAGCCTCAGTCCCCAGCAGAGCCTGTGTCTCACCCCCTCACAGGACAGAGCT GTATCTGCATAGAGCTGGTCTCACTGTGGCGCAGGCCCCGGGGGGAGTGCCTGTGCTGTC AGGAAGAGGGGGTGCTGGTTTGAGGGCCGCCACTGCAGTTCTGCTAGGTCTGCTTCCTGC CCAGGAAGGTGCCTGCACATGAGAGGAGAGAAATACACGTCTGATAAGACTTCATGAAAT AATAATTATAGCAAAGAACAGTTTGGTGGTCTTTTCTCTTCCACTGATTTTTCTGTAATG ACATTATACCTTTATTACCTCTTTATTTTATTACCTCTATAATAAAATGATACCTTTCAT GTACAGAGCCCTCAATGGGGCCGATTTTCAGTTGTGTA OMIM ID 602441