| Entrez gene ID | | 115727 |
|
| Official gene symbol | | RASGRP4 |
|
| Full name | | RAS guanyl releasing protein 4 |
|
| Aliases | | ,-, |
|
| Gene summary | | The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
|
| Location | | Chromosome: 19 Locus: 19q13.1 |
|
| Gene position | | 38916945 - 38899698 Map Viewer |
|
| Gene orientation | | minus |
|
| Gene size | | 17248 bp |
|
| Gene sequence |
| |
|
|
