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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for Nfasc (Rattus norvegicus)
(Information is obtained from NCBI Gene database)
Entrez gene ID116690
Official gene symbolNfasc
Full nameneurofascin
AliasesNF
Gene summaryThis gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
LocationChromosome: 13   Locus: 13q13
Gene position45450549 - 45637876  Map Viewer
Gene orientationminus
Gene size187328 bp
Gene sequence