Entrez gene ID | | 116984 |
Official gene symbol | | ARAP2 |
Full name | | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Aliases | | ,CENTD1,FLJ13675,FLJ44916,KIAA0580,PARX, |
Gene summary | | The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4p14 |
Gene position | | 36245979 - 36067622 Map Viewer |
Gene orientation | | minus |
Gene size | | 178358 bp |
Gene sequence |
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OMIM ID | | 606645 |
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