Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CCR3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1232
Official gene symbolCCR3
Full namechemokine (C-C motif) receptor 3
Aliases,CC-CKR-3,CD193,CKR3,CMKBR3,MGC102841,
Gene summaryThe protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p21.3
Gene position46283872 - 46308197  Map Viewer
Gene orientationplus
Gene size24326 bp
Gene sequence
OMIM ID601268