Entrez gene ID | | 1238 |
Official gene symbol | | ACKR2 |
Full name | | chemokine binding protein 2 |
Aliases | | ,CCBP2,CCR10,CCR9,CMKBR9,D6,hD6, |
Gene summary | | This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p21.3 |
Gene position | | 42850964 - 42908775 Map Viewer |
Gene orientation | | plus |
Gene size | | 57812 bp |
Gene sequence |
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OMIM ID | | 602648 |
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