Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ABCC2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1244
Official gene symbolABCC2
Full nameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases,ABC30,CMOAT,DJS,KIAA1010,MRP2,cMRP,
Gene summaryThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q24
Gene position101542463 - 101611662  Map Viewer
Gene orientationplus
Gene size69200 bp
Gene sequence
OMIM ID601107