Entrez gene ID | | 1244 |
Official gene symbol | | ABCC2 |
Full name | | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
Aliases | | ,ABC30,CMOAT,DJS,KIAA1010,MRP2,cMRP, |
Gene summary | | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q24 |
Gene position | | 101542463 - 101611662 Map Viewer |
Gene orientation | | plus |
Gene size | | 69200 bp |
Gene sequence |
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OMIM ID | | 601107 |
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