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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NLRP8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID126205
Official gene symbolNLRP8
Full nameNLR family, pyrin domain containing 8
Aliases,CLR19.2,NALP8,NOD16,PAN4,
Gene summaryNALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]
LocationChromosome: 19   Locus: 19q13.43
Gene position56459198 - 56499995  Map Viewer
Gene orientationplus
Gene size40798 bp
Gene sequence
OMIM ID609659