Entrez gene ID | | 126205 |
Official gene symbol | | NLRP8 |
Full name | | NLR family, pyrin domain containing 8 |
Aliases | | ,CLR19.2,NALP8,NOD16,PAN4, |
Gene summary | | NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM] |
Location | | Chromosome: 19 Locus: 19q13.43 |
Gene position | | 56459198 - 56499995 Map Viewer |
Gene orientation | | plus |
Gene size | | 40798 bp |
Gene sequence |
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OMIM ID | | 609659 |
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