| Entrez gene ID | | 12741 |
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| Official gene symbol | | Cldn5 |
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| Full name | | claudin 5 |
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| Aliases | | AI854493,MBEC1,MGC102088,Tmvcf |
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| Gene summary | | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a critical component of endothelial tight junctions that control pericellular permeability. The knockout mice lacking this gene died within 10 h of birth and the blood-brain barrier in these mice against small molecules was selectively affected. This gene is expressed strongly in endothelium of normal lung and plays a regulation role during acrolein-induced acute lung injury. [provided by RefSeq] |
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| Location | | Chromosome: 16 Locus: 16 A3|16 11.65 cM |
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| Gene position | | 18776940 - 18778353 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 1414 bp |
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| Gene sequence |
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