Entrez gene ID | | 128 |
Official gene symbol | | ADH5 |
Full name | | alcohol dehydrogenase 5 (class III), chi polypeptide |
Aliases | | ,ADH-3,ADHX,FDH,GSNOR, |
Gene summary | | This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q21-q25 |
Gene position | | 100009931 - 99992129 Map Viewer |
Gene orientation | | minus |
Gene size | | 17803 bp |
Gene sequence |
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OMIM ID | | 103710 |
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