Entrez gene ID | | 130013 |
Official gene symbol | | ACMSD |
Full name | | aminocarboxymuconate semialdehyde decarboxylase |
Aliases | | ,-, |
Gene summary | | The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2q21.3 |
Gene position | | 135596186 - 135659604 Map Viewer |
Gene orientation | | plus |
Gene size | | 63419 bp |
Gene sequence |
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