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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for COMT (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1312
Official gene symbolCOMT
Full namecatechol-O-methyltransferase
Aliases,-,
Gene summaryCatechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q11.21-q11.23|22q1
Gene position19929263 - 19957498  Map Viewer
Gene orientationplus
Gene size28236 bp
Gene sequence