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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP3K8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1326
Official gene symbolMAP3K8
Full namemitogen-activated protein kinase kinase kinase 8
Aliases,COT,EST,ESTF,FLJ10486,MEKK8,TPL2,Tpl-2,c-COT,
Gene summaryThis gene was identified by its oncogenic transforming activity in cells. The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the MAP kinase and JNK kinase pathways. This kinase was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This kinase was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. Studies of a similar gene in rat suggested the direct involvement of this kinase in the proteolysis of NF-kappaB1,p105 (NFKB1). This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. [provided by RefSeq]
LocationChromosome: 10   Locus: 10p11.23
Gene position30722866 - 30750761  Map Viewer
Gene orientationplus
Gene size27896 bp
Gene sequence
OMIM ID191195