Entrez gene ID | | 135138 |
Official gene symbol | | PACRG |
Full name | | PARK2 co-regulated |
Aliases | | ,FLJ32724,GLUP,HAK005771,PARK2CRG,RP3-495O10.2, |
Gene summary | | This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6q26 |
Gene position | | 163148164 - 163736524 Map Viewer |
Gene orientation | | plus |
Gene size | | 588361 bp |
Gene sequence |
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OMIM ID | | 608427 |
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