Entrez gene ID | | 136319 |
Official gene symbol | | MTPN |
Full name | | myotrophin |
Aliases | | ,FLJ31098,FLJ99857,GCDP,V-1, |
Gene summary | | The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q33 |
Gene position | | 135662204 - 135611503 Map Viewer |
Gene orientation | | minus |
Gene size | | 50702 bp |
Gene sequence |
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OMIM ID | | 606484 |
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