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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MTPN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID136319
Official gene symbolMTPN
Full namemyotrophin
Aliases,FLJ31098,FLJ99857,GCDP,V-1,
Gene summaryThe transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q33
Gene position135662204 - 135611503  Map Viewer
Gene orientationminus
Gene size50702 bp
Gene sequence
OMIM ID606484