Entrez gene ID | | 13690 |
Official gene symbol | | Eif4g2 |
Full name | | eukaryotic translation initiation factor 4, gamma 2 |
Aliases | | AA589388,DAP-5,E130105L11Rik,Nat1,Natm1,p97 |
Gene summary | | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7 F1|7 51.52 cM |
Gene position | | 118226544 - 118211499 Map Viewer |
Gene orientation | | minus |
Gene size | | 15046 bp |
Gene sequence |
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