Entrez gene ID | | 1388 |
Official gene symbol | | ATF6B |
Full name | | activating transcription factor 6 beta |
Aliases | | ,CREB-RP,CREBL1,FLJ10066,G13, |
Gene summary | | The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6p21.3 |
Gene position | | 32096030 - 32083045 Map Viewer |
Gene orientation | | minus |
Gene size | | 12986 bp |
Gene sequence |
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OMIM ID | | 600984 |