Entrez gene ID | | 1389 |
Official gene symbol | | CREBL2 |
Full name | | cAMP responsive element binding protein-like 2 |
Aliases | | ,MGC117311,MGC138362, |
Gene summary | | cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12p13 |
Gene position | | 12764831 - 12798041 Map Viewer |
Gene orientation | | plus |
Gene size | | 33211 bp |
Gene sequence |
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OMIM ID | | 603476 |
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