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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CREBL2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1389
Official gene symbolCREBL2
Full namecAMP responsive element binding protein-like 2
Aliases,MGC117311,MGC138362,
Gene summarycAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p13
Gene position12764831 - 12798041  Map Viewer
Gene orientationplus
Gene size33211 bp
Gene sequence
OMIM ID603476