| Entrez gene ID | | 147 |
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| Official gene symbol | | ADRA1B |
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| Full name | | adrenergic, alpha-1B-, receptor |
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| Aliases | | ,ADRA1,ALPHA1BAR, |
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| Gene summary | | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq] |
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| Location | | Chromosome: 5 Locus: 5q23-q32 |
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| Gene position | | 159343740 - 159400017 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 56278 bp |
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| Gene sequence |
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| OMIM ID | | 104220 |
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