Entrez gene ID | | 14776 |
Official gene symbol | | Gpx2 |
Full name | | glutathione peroxidase 2 |
Aliases | | GPx-GI,GSHPx-2,GSHPx-GI |
Gene summary | | This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Knockout studies in mice indicate that mRNA expression and activity of this enzyme are induced by luminal microflora, suggesting a role for this peroxidase in preventing inflammation in the GI tract. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12 C3|12 36.0 cM |
Gene position | | 77896541 - 77893322 Map Viewer |
Gene orientation | | minus |
Gene size | | 3220 bp |
Gene sequence |
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