Entrez gene ID | | 150465 |
Official gene symbol | | TTL |
Full name | | tubulin tyrosine ligase |
Aliases | | ,MGC46235, |
Gene summary | | TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2q13 |
Gene position | | 113239743 - 113290223 Map Viewer |
Gene orientation | | plus |
Gene size | | 50481 bp |
Gene sequence |
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OMIM ID | | 608291 |
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