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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TTL (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID150465
Official gene symbolTTL
Full nametubulin tyrosine ligase
Aliases,MGC46235,
Gene summaryTTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM]
LocationChromosome: 2   Locus: 2q13
Gene position113239743 - 113290223  Map Viewer
Gene orientationplus
Gene size50481 bp
Gene sequence
OMIM ID608291