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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CTSB (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1508
Official gene symbolCTSB
Full namecathepsin B
Aliases,APPS,CPSB,
Gene summaryThe protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
LocationChromosome: 8   Locus: 8p22
Gene position11725646 - 11700033  Map Viewer
Gene orientationminus
Gene size25614 bp
Gene sequence
OMIM ID116810