| Entrez gene ID | | 151306 |
|
| Official gene symbol | | GPBAR1 |
|
| Full name | | G protein-coupled bile acid receptor 1 |
|
| Aliases | | ,BG37,GPCR,GPCR19,GPR131,M-BAR,MGC40597,TGR5, |
|
| Gene summary | | This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq] |
|
| Location | | Chromosome: 2 Locus: 2q35 |
|
| Gene position | | 219125738 - 219128582 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 2845 bp |
|
| Gene sequence |
| |
|
| OMIM ID | | 610147 |
|
|
|
