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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CYP1A2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1544 Official gene symbol CYP1A2 Full name cytochrome P450, family 1, subfamily A, polypeptide 2 Aliases ,CP12,P3-450,P450(PA), Gene summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq] Location Chromosome: 15   Locus: 15q24.1 Gene position 75041184 - 75048941  Map Viewer Gene orientation plus Gene size 7758 bp Gene sequence >CYP1A2:45831741..45839498:Length=7758 GAAGCTCCACACCAGCCATTACAACCCTGCCAATCTCAAGCACCTGCCTCTACAGGTACC TTTCTTGGGACCAATTTACAATCTCTGGGATCCCCAACTATAGAACCTGGAAGCTAGTGG GGACAGAAAGACGGGGAGCCTGGGCTAGGTGTAGGGGTCCTGAGTTCCGGGCTTTGCTAC CCAGCTCTTGACTTCTGTTTCCCGATTTTAAATGAGCAGTTTGGACTAAGCCATTTTTAA GGAGAGCGATGGGGAGGGCTTCCCCCTTAGCACAAGGGCAGCCCTGGCCCTGGCTGAAGC CCAACCCCAACCTCCAAGACTGTGAGAGGATGGGGACTCATCCCTGGAGGAGGTGCCCCT CCTGGTATTGATAAAGAATGCCCTGGGGAGGGGGCATCACAGGCTATTTGAACCAGCCCT GGGACCTTGGCCACCTCAGTGTCACTGGGTAGGGGGAACTCCTGGTCCCTTGGGTATATG GAAGGTATCAGCAGAAAGCCAGCACTGGCAGGGACTCTTTGGTACAATACCCAGCATGCA TGCTGTGCCAGGGGCTGACAAGGGTGCTGTCCTTGGCTTCCCCATTTTGGAGTGGTCACT TGCCTCTACTCCAGCCCCAGAAGTGGAAACTGAGATGATGTGTGGAGGAGAGAGCCAGCG TTCATGTTGGGAATCTTGAGGCTCCTTTCCAGCTCTCAGATTCTGTGATGCTCAAAGGGT GAGCTCTGTGGGCCCAGGACGCATGGTAGATGGAGCTTAGTCTTTCTGGTATCCAGCTGG GAGCCAAGCACAGAACACGCATCAGTGTTTATCAAATGACTGAGGAAATGAATGAATGAA TGTCTCCATCTCAACCCTCAGCCTGGTCCCTCCTTTTTTCCCTGCAGTTGGTACAGATGG CATTGTCCCAGTCTGTTCCCTTCTCGGCCACAGAGCTTCTCCTGGCCTCTGCCATCTTCT GCCTGGTATTCTGGGTGCTCAAGGGTTTGAGGCCTCGGGTCCCCAAAGGCCTGAAAAGTC CACCAGAGCCATGGGGCTGGCCCTTGCTCGGGCATGTGCTGACCCTGGGGAAGAACCCGC ACCTGGCACTGTCAAGGATGAGCCAGCGCTACGGGGACGTCCTGCAGATCCGCATTGGCT CCACGCCCGTGCTGGTGCTGAGCCGCCTGGACACCATCCGGCAGGCCCTGGTGCGGCAGG GCGACGATTTCAAGGGCCGGCCTGACCTCTACACCTCCACCCTCATCACTGATGGCCAGA GCTTGACCTTCAGCACAGACTCTGGACCGGTGTGGGCTGCCCGCCGGCGCCTGGCCCAGA ATGCCCTCAACACCTTCTCCATCGCCTCTGACCCAGCTTCCTCATCCTCCTGCTACCTGG AGGAGCATGTGAGCAAGGAGGCTAAGGCCCTGATCAGCAGGTTGCAGGAGCTGATGGCAG GGCCTGGGCACTTCGACCCTTACAATCAGGTGGTGGTGTCAGTGGCCAACGTCATTGGTG CCATGTGCTTCGGACAGCACTTCCCTGAGAGTAGCGATGAGATGCTCAGCCTCGTGAAGA ACACTCATGAGTTCGTGGAGACTGCCTCCTCCGGGAACCCCCTGGACTTCTTCCCCATCC TTCGCTACCTGCCTAACCCTGCCCTGCAGAGGTTCAAGGCCTTCAACCAGAGGTTCCTGT GGTTCCTGCAGAAAACAGTCCAGGAGCACTATCAGGACTTTGACAAGGTGAGCCCGGGGT GCAGGTGGCAAGGGGCACCTTGCAGGGCCTGGGTGCAGCCCCTCCCTCCCAGCTCCAGCA TGCCCACACAGCTGCTGTGTTGCCAAGGCCTAGGAAGGCTCTGGACACCTCAGACCAGCT GTGTGACCTGGAGCCGACTCTTCCCCTTCTCTGGGCCTCAGTTTCCTCATCCTTGAAGCC CCCTTCTCAGGGCTCCTCAAAGCCCCCAAGAAAAAAGCCCTGGAAATGGGGCCCTAGCAG AGTCCTGCAATGTGGGGGGCCTATGAGTGAGAAAGCTTTCATTCTGCAGAAACCTAAACC CCAACAGAGGCTAATCCCCAGCTCTGGTGTCACGTTGCTTCCCTGTGTTCACACTAACCT TTTCCTTCTTTGAAATTGGACCCCTGGTGTTATTGGGAGGAAGGGTCAATGGGGCATAAA ATGACACTTTAAGCCATACCCAGGGCTGCTACCAGCTCCTGCTGCAAGCTGCAACCCCCT GCCTAGAGACCAAGTTGGGAGGATAGGGGGGTACCCAGCCACCAGGTACAGGCCAGGGGA GTGGAGCAACGTTCAGCCTTTGACCTTGGAAGTGCCAGAGGTGCCCCTAAGCTTGTGCCC CCTCAGAACAGTGTCCGGGACATCACGGGTGCCCTGTTCAAGCACAGCAAGAAGGGGCCT AGAGCCAGCGGCAACCTCATCCCACAGGAGAAGATTGTCAACCTTGTCAATGACATCTTT GGAGCAGGTAGGAACCAGAACCTTGCCCCTCCATCCAACAATGCCTGCTGTTCACCCACA GCCTTGCCCAGCCCCTCAGTCCATGAAATAACCCACCAACCCTACACCAGATGGTACAAC ATACTGAGATCTGGCTTGGGATCAGGGTTTGAGCCTGGGCTATGCCACCAATTCCCAGTG GAGAAACAGCAAAGTCCTTCTCCTCCCCTAGGCTTCAGTTTCCCCATCTGAACAATAAGG TGTTCTCTGGCCTGTAAGTCTAGGCCCCTATAATTCCAGCAGCTAATTCTGAAACCTGTA TCTCAAGTTTATGTTGAAGAGACCCAGCCTCTGTCTTCAGGAAACTCACAGGCTAGGGCC AGAGAAAGCTAATGCTGGATACATACATAGCAGATACTTGGGAAATGATGGTTTCCTTGT TTCTGTCTTCCTTCTTTCCTCACCTTACACTACACGGTTCAGGATTTGACACAGTCACCA CAGCCATCTCCTGGAGCCTCATGTACCTTGTGACCAAGCCTGAGATACAGAGGAAGATCC AGAAGGAGCTGGGTACATGGGGGCCCCCAACCCTATAGCCAGGAGAAGCCTTGAGACCCA GGTTGTTTGTTCAGTCTACAAACACCTGTTATGTGCCTGCTGTGTGCAAGCCCTGGGCAC ACAGTAGTGCCTGCCCTTGCCTAGAAGATGTGGGAGGTTAGTGGGGTCGCAGACTTGTGA ATAGACAGTCTTACATAAGAGTGACATGGGGTATAAGAGGGGATAATTCATGGGGCAGTT AGGGCAGCCCCTGAGCTCTGCTTGTCCTCTGTGTTCTACAGACACTGTGATTGGCAGGGA GCGGCGGCCCCGGCTCTCTGACAGACCCCAGCTGCCCTACTTGGAGGCCTTCATCCTGGA GACCTTCCGACACTCCTCCTTCTTGCCCTTCACCATCCCCCACAGGTGAGGCCTGCCGGT TCTGCCCTCCCACCTCTAAAGTGCTTGCCATGTTTTCTCTTCCTGGCTTCTCAGCCCTGG CCCTGGCTCAGCATCTCCTTCCCGACCTCGTTCCCCACAGATCCCGGCCTCAGTCTGCCC CCATCCAGTCCAAACATAATCTAACCCCCAGCTCTCAGGAGAAAGTTCCACTTGTGATCT CAGCGCTCATTCCCCTCTGTTCATATTCCCTCCCTCCCAGTGCCCTCTGTGCCAGTCAGG TCGGCCTCACCCTCACAAGCATGACCCTATTGGCCTCCAATCTTGCTAACGCTGAACCTT CTGCCTGGAATACCTTCTAGCCTCTTCTCTGACCACCAGAATCCTACCCTTGCTCAAAGT CAATGCCGACACGAGCTTCCTCTCCCCAGAAGCCTTTTGACTCATCCAGCTGGCACAGCT TCATTCCTGATGTCTTATAGGACTTACAGCCATCAGCCCTTGATCATGCCCTGGAATTTT AACAATGTCAAGAGAGTTAGTGAGCATTTACTTCTACCCAAACGTTGTTCTAGTTATTCC TGCAGTAAGAGGCCTGAATCCCCAGCCAGGCTAGAAATTCCCCGGGGCTGCCCCAGGCTG CCTGCTGCTTTTTTTTTTTTTTTTTTTTTTTTCATAGAAAATAGAAAAACATTTATCTGA AATTGCCTGCTTCTTGGCTCCAGAGAACAGCCAAGTGCGCAGCCAGGCGCAAAGAGAAGT TTAGTAAATACTTGCTGAAGTTAAAGAACAGGACGCAAGGAAGAGGGAGGATGTTTCTAC CTCTTCCCTGTTCCTCCCCTCCCCTCCCAGTGTAGGGATGGAGATGGCGGTGGGCAGGCT GTCTGGATGGGGTGGAGGTAGGAGCAACACATGCCCCAGCTTTCCAGCCCTGAGCCTCAC AGTGCCCTCTTCCCTCCTCAGCACAACAAGGGACACAACGCTGAATGGCTTCTACATCCC CAAGAAATGCTGTGTCTTCGTAAACCAGTGGCAGGTCAACCATGACCCGTGAGTACATAC CCCTCACGAAAAAATGTGTGCAGGTTCAGCAGTCAGGAAGGCTGTTTGTCCCTGCTAGGA ACTGTTTATATAATGAAAGGAGGGGACCTCAATTGCTATAGTCTGCTCTAAGTGACGATA TTTACAAAAGTTTCACAAACTTTAGTGCACAGGAATCAACTAGGATGGCCAGGCGCAGTG GCTCAAGCCTATAATCCCAGCAGTTTGGGAGGCCGAGGCAGGCAGATCACTTGAGGTCAG GAGTTTGAGACCAGCCTGGGCAACATGGTGAAACCCTATCTCTACTAAAAATACAAAACA AAAATTAGCCGGACATGGTGGTGCGCCTATAATCCCAGCTACTCCAGAGGCTGAGGCAGG AGAATTGCTTGAACTCTGGAGGTAGAGGCTGCAGTGAGCCGAGATCGCTCCACTGCACTC CAGCCTGGGTGACGGAGTGAGACTCTGCCTCAAAAAAAAAAAAAAAAAATCAACCAAGAC GTTTGTTACAGGTGATGGTTCCCCCAGGATTCTACTGTGGTATCTAAGGTGGGGTACCTC AGGCGATTCTGATGTGAATGGCTCAGAGACCTCTCTTTGGAAAGCCCCACTTTAGTGTAT AGGTAGGGGGACCATATATATAATTTACCATCCACACTGGGACATTTGAGTGTGAAAATG CTATCAATGTTTATGCTAGTCATCATTACTCCAAAACAATAAACATAAGCCAGGACATAC TGTTGAGGCCCCTTAGGAGGCATATTTTGAGTAGGATGAAGAAACGTATGTCTTTCTTTC TTCCTTTCACTTTAATTTTTAAATAGAGACAAGGTCTTCCTATGTGGTCCAGGCTGGTTT TGAACTCCTGGGTTCAAGGGATCTTCCTGCCTCAGCCTCCCAAAGTGCTAGGGTTACGGG TGTAAGCCACCAAACCCAGCCTGTTTTTCTTCTTTTAATTTCTTTTAGATAAAGCATTAT TTAAAGTAAATTAATATTAAAAGGCACTATCTTTAAGGCTGGTCATTTTAGAGAGAGCTT TGTAAAAGAAATAAGCATCAGGCCAGGTGTGGTGACTCATGCCTGTAACCCCAGCACTTT GGGAGTCCGAGGAAGGTGGATCGCTTGAGCTCATGAGTCTGAGACCAGTGAAACCCCGTC TCTGCAAAAAAAAAAAAAAAAAAAAATACAAAAATTAGCCGGATATGGTGCCTGTAGTCC CAGCTACACGGGAGGCTCAGGTGGGTGGTTGGCTTGAGCTGGGGAGGCAGAGAGAGTGCA GTGAGCTGAGATCGCACCACTGTACTCCAGCCTGGGTGATAGGAGCCGGAGGGTGTCTCA AAAAAAAAAAAAGAAAGAAAAGAAAAAGAAATAAGCATCAAAGTTCAGTTTGGTTCCTTC CCACCTACCCTTCATTGCTTTCAAAGTGCCCTCACACTTGTGTTCTCAACAGAAGTCTCC CTCCCCCAGGCACCTCCTCCCAGGGCCTCTCCAGCCCTGAGGTCCCATCTCCTCTGTTCC TCTTGCAGAGAGCTGTGGGAGGACCCCTCTGAGTTCCGGCCTGAGCGGTTCCTCACCGCC GATGGCACTGCCATTAACAAGCCCTTGAGTGAGAAGATGATGCTGTTTGGCATGGGCAAG CGCCGGTGTATCGGGGAAGTCCTGGCCAAGTGGGAGATCTTCCTCTTCCTGGCCATCCTG CTACAGCAACTGGAGTTCAGCGTGCCGCCGGGCGTGAAAGTCGACCTGACCCCCATCTAC GGGCTGACCATGAAGCACGCCCGCTGTGAACATGTCCAGGCGCGGCTGCGCTTCTCCATC AACTGAAGAAGACACCACCATTCTGAGGCCAGGGAGCGAGTGGGGGCCAGCCACGGGGAC TCAGCCCTTGTTTCTCTTCCTTTCTTTTTTTAAAAAATAGCAGCTTTAGCCAAGTGCAGG GCCTGTAATCCCAGCATTTTAGGAGGCCAAGGTTGGAGGATCATTTGAGCCCAGGAATTG GAAAGCAGCCTGGCCAACATAGTGGGACCCTGTCTCTACAAAAAAAAAATTTGCCAAGAG CCTGAGTGACAGAGCAAGACCCCATCTCAAAAAAAAAAACAAACAAACAAAAAAAAAACC ATATATATACATATATATATAGCAGCTTTATGGAGATATAATTCTTATGCCATATAATTC ACCTTCTTTTTTTTTTTTTGTCTGAGACAGAATCTCAGTCTGTCACCCAGGTTGGAGTGC AGTGGCGTGATCTCAGCTCACTGCAACCTCCACCTCGCAGGTTCAAGCAATCCTCCCACT TCAGCCTCCCAAGCACCTGGGATTACAAGCATGAGTCACTACGCCTGGCTGATTTTTGTA GTTTTAGTGGAGATGGGGTTTCACCATGTTGGCCAGGCTTGTCTCGAACTCCTGACCCCA AGTTATCCACCTGCCTTGGCTTCCCAAAGTCCTGGGATTACAGGTGTGAGCCACCACATC CAGCCTAACTTACATTCTTAAAGTGTCGAATGACTTCTAGTGTAGAATTGTGCAACCATC ACCAGAATTAATTTTATTATTCTTATTATTTTTGAGACAGAGTCTTACTCTGTTGCCAGG CTGGAGTGCAGTGGCGCGATCTCAGCTCACTACAACCTCCGCCTCCCATGTTCAAGCGAT TCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTATAGGCATGCGCCACCATGGCCAGCTA ATTTTTGTATTTTTAGTAGAGACGAGGTTTCACTGTGTTGGCCAGGATGGTCTCCATCTC TTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTAACAGGTATGAACC ACCGCGCCCAGCCTTTTTGTTTTTTTTTTTTTTGAGACAGAGTCTTCCTCTGTCTCCTAA GCTGGAGTGCAGTGGCATCATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGC TTCTCCAGCCTCAGCCTCCCAAGTAGCTGAGACTACAGGCACACACCACCACGCCTGGCT AATTTTTGTATTTTTAGTAGAGACGGGTTTCACCATGTTGGCTAGACTAGTCTCAAACTC CTGACCTCAAGTGATCTGCCCGCCTCGACCTCTCTCAAAGTGCTGGCATTACAGGTGTGA GCCACGGTGCCCGGCCCACAATTAATTTTAGAACATTTTCATCACCCCTAAAAGAAACCC TGCACCCATTAGCAGTCCCTCCACATTTCCCCCTAGCCTGCCTCCCCTGCCTCACCAGCC CTGGCAACTGCTAATCTACTTTCTGTGTCTATGGATTTGCCTTCTCTAAACATTTCATAT AAATGGAATTACACAATG OMIM ID 124060