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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for Htr2c (Mus musculus)
(Information is obtained from NCBI Gene database)
Entrez gene ID15560
Official gene symbolHtr2c
Full name5-hydroxytryptamine (serotonin) receptor 2C
Aliases5-HT2C,5-HT2cR,5-HTR2C,5HT1c,Htr1c,SR1
Gene summarySerotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq]
LocationChromosome: 0   Locus: X D-F4|X 66.15 cM
Gene position143397056 - 143631820  Map Viewer
Gene orientationplus
Gene size234765 bp
Gene sequence