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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CYP8B1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1582 Official gene symbol CYP8B1 Full name cytochrome P450, family 8, subfamily B, polypeptide 1 Aliases ,CP8B,CYP12,FLJ17826, Gene summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq] Location Chromosome: 3   Locus: 3p22-p21.3 Gene position 42917633 - 42913684  Map Viewer Gene orientation minus Gene size 3950 bp Gene sequence >CYP8B1:complement(42853684..42857633):Length=3950 GAAGGTGCAAGAGCTGTCTGAAAAGGTCAGAGCAAAGCATGAAGCTGGTGAGCAGCTGTG ACCATAGCTGGAAGCTTCTCTCTGAGCTTTCTCCTGGTTACCTCCTCCTCCCCTACGTGA CCAGTCAGCCAAGTGTTAAGTCCAGGGGAACATTTTGCTGCTTCCAAGTACTGTCTCACT AGTGTTATTTGCCATAACTTGCGGCCACAGGGCAAGGTCCAGGTGCTCAGACCTTTACAT CCTGGACTTTCCAAGGCCTCCCAAAGCTCTCTGGCACCCAGGGAACAGTGTGCGTGTCGA GAGCTTAATCCGCAGGAGCATAGCCATGGTTCTCTGGGGTCCAGTGCTGGGAGCTCTGCT GGTGGTCATTGCTGGATACCTGTGCCTGCCAGGGATGCTCCGACAACGCAGGCCATGGGA GCCCCCTCTGGACAAGGGTACCGTGCCCTGGCTTGGCCATGCCATGGCTTTCCGGAAGAA TATGTTTGAATTTCTGAAGCGCATGAGGACCAAGCATGGGGATGTGTTCACAGTGCAGCT AGGGGGCCAGTACTTCACCTTCGTCATGGACCCCCTCTCCTTTGGCTCCATCCTCAAGGA CACACAGAGAAAACTAGACTTTGGGCAATATGCAAAAAAACTGGTGCTGAAGGTATTTGG ATACCGTTCAGTGCAAGGGGACCATGAGATGATACACTCAGCCAGCACCAAGCATCTGAG GGGGGATGGCTTGAAGGATCTTAATGAGACCATGCTGGACAGCCTGTCCTTTGTAATGCT GACGTCCAAAGGCTGGAGTCTGGATGCCAGTTGCTGGCATGAGGACAGCCTCTTTCGCTT CTGCTATTACATCTTGTTCACAGCTGGCTACCTGAGCTTGTTCGGCTACACGAAGGACAA GGAGCAGGACCTGCTACAGGCAGGAGAGTTATTCATGGAGTTCCGCAAGTTTGACCTTCT TTTCCCAAGGTTTGTCTACTCCCTGCTGTGGCCCCGGGAGTGGCTAGAAGTGGGCCGACT CCAGCGTCTCTTTCACAAGATGCTCTCCGTGAGCCACAGCCAGGAGAAGGAGGGCATCAG CAACTGGCTGGGCAACATGCTTCAGTTTCTGAGGGAGCAGGGGGTACCCTCAGCTATGCA GGACAAGTTCAACTTCATGATGCTCTGGGCCTCCCAGGGGAACACGGGGCCTACCTCTTT CTGGGCCCTCTTGTACCTCCTGAAGCACCCAGAAGCTATTCGGGCTGTGAGGGAGGAAGC TACCCAGGTCCTGGGTGAGGCCAGGCTGGAGACCAAGCAGTCCTTTGCCTTCAAACTCGG TGCCCTGCAACACACCCCAGTTCTAGACAGCGTGGTGGAGGAGACGCTGCGGCTGAGGGC TGCACCCACCCTCCTCAGGTTGGTTCATGAAGACTATACCCTGAAGATGTCCAGTGGGCA GGAGTATCTGTTCCGCCATGGAGACATCCTGGCCCTCTTTCCCTACCTCTCAGTGCACAT GGACCCTGACATCCACCCTGAGCCCACCGTCTTCAAGTACGATCGCTTCCTCAACCCTAA TGGCAGCCGGAAAGTGGACTTCTTCAAGACAGGCAAGAAGATCCACCACTACACCATGCC CTGGGGTTCGGGCGTTTCCATCTGCCCTGGGAGGTTCTTTGCACTCAGTGAGGTGAAGCT CTTTATCCTGCTTATGGTCACACACTTTGACTTAGAGTTGGTGGACCCTGACACACCACT ACCCCATGTTGACCCGCAGCGCTGGGGTTTTGGCACCATGCAGCCCAGCCACGATGTGCG CTTCCGCTACCGCCTGCATCCTACAGAGTGAGCTTGGCCAAGCCAGCTGCAAACCTGGCC AGAGGAGTTCTATTGCATCTCTCACCTGTTCTCACCCCTCTGCAGCCCCAAGACCCCACT GGCCACCCCTCCCTCTGGTCCTGTGGCACCCCCTACCTCTGTTCTGCCTGTCCTCGCTCT CTCCCCGCCTAGTCATCTGACAGGCTTATCATTCTCTTTAAAATACCATCTCTCAGAGTG GGTTCTGCCGAACCCTCCTCTCACAGGAAGTCCAGAGGAAGGGGGAGTATCTGTGGGCAA CTTGGTTTGGGAGATGATGCCTGCCTTGAGAAGTCCTGAGTACAGAGACTGGTTCCCCCC AGACACGAGTAACATGGCATCTTGCAAACATCAGCCTCCACTCTCCCAGCTTGCTTTAGT TTTTTCAGCAACACTTATCCCACATCCTATGGAATTCAGGTTCTAGAACAGTGTCATCCA ACATAAATATGAAGCAAGCTACATGAGTAGTGGGGTTTTTTGGTTTTGTTTGTTTGTTTT GAGACAGAGTCTTGCTCTGTCGCCGAGGCTGCAGTGCAGCGGTGCGATCTCTGCTCACTG CAACCTCTGCCTCCTGGGTTTAAGCAATTCTCCTGCCTCAGCCTCCCCAGTAGCTGGGAT TACAGGCACCTACCACCTTGCCCAGCTAATTTAGTTTCCTGGTAAACACATTTTTAAAAA GTAAAATGAAACAATTCATTTTTATAATATACTTTACTTAATCCAATATATCCAAAATAT TGGCATTTCAACGTGATCACTATTAAAAATTTTAACGTAATAGTTTTTACCTTCCCTTTT TCATCCTGTCTTCAAAGTCTGGTATGTACTGTACTTTTGCAGTTCTTCCCAGTTCAGACT AGCCACATTCCAAGTGCTTAATTGCCGTGTGTGGCAGGTGGCTGCCCTATTGGATAGCAC AGGTCTAGAGAAATGATACCTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTTGCCCAG GCTGCAGTGCAGTGGTGTGATCTTGGCTCACTACAACCTCTGCCTCCCGGGTTCAAGTAA TTCTCCTGCCTCAGGCTTCTGAGTAGCTGGGATTATAGGTGCGCACCACCACACCCGGCT AGTTTCTGTATTTTTAGTAGAGACGGCGTTTCACCATTTTGGCCGGCCTCCTCGGCCTCC CAAAGTTCTGGGATTACAGGCATGAGCCACTGTGCCCAGTCAGGATGTCTTTAATGTAGG AATCATTCAAGATCCCTCCTCAGTGCCCATGTCTCCCCCACCTCAGGGTGCTGTCAACCC TCCCTTGGTTTCCATGATCATTGCTGAACTCAGAGCTTTCTTCTATCCCCAGACCCACAT GGGAGTCTCCCAGCACCTCTGACTCAGCTTGGCCAATGCAGAACTTGGCATCTGAACCCC TGCCTCTTCCCTGAACCACTCCTCCTCCTGATTTCCCTGCTCTCTCTGCTCAGAACACTA CCATTCACCCCATCTCCCAGAGACACTCTCCCTCCTCCTCTTTCACCTTCATACAAGCAG GCCCCCGTCCTATCAGTACACCCCCCTGTGATGCCTCTGAAATATGTACCCTCCTCCCCT CTCCTACTGTCATTCTTATACCTGTGATCTCTGCGTTTCTCTTCTACACTGCTGCCAGAG GCCTTTTTGCCAAAAGCACTGCTGATTGTCACTCTTTTACTTTCCTGGTTCCCCTTTGAC TTCACACACTTGACGTTTACATTTTGTCACAGTTGGTCCCCCTTGCCTTCACATACCTGA TGTTTAAATTTTGTCACGGTTAGTCTCCAAACTTCTCAACTTTGCCAGCTTTCTCCAATG AAACCATCAGTAGAGACATTGCTGTTCCTGCCCATCCCAGTGCCAGCTACTCCTTCCTGG AAGCCTTCCTGGATTTCACGCATCCCATCCTCTGGCCAGAAATGGCCTCCGAACTGTGCA GCTCCTGCAGCACCATTTGTATCATAGCATATCTGTTATGTGTCGTTGCTTTCTGTGTCT TGGTTTCTGCCTGCTGCCCACTTCCCTAGACTGGAGCCTACTGGGGCATGGTATTTTATT CATTTCTGACCTCCAATTCCCTAAGTGGAGATTAAATGTTAGAAACCTGA OMIM ID 602172