Entrez gene ID | | 1603 |
Official gene symbol | | DAD1 |
Full name | | defender against cell death 1 |
Aliases | | ,OST2, |
Gene summary | | DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q11-q12 |
Gene position | | 23058143 - 23033807 Map Viewer |
Gene orientation | | minus |
Gene size | | 24337 bp |
Gene sequence |
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OMIM ID | | 600243 |
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