| Entrez gene ID | | 1630 |
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| Official gene symbol | | DCC |
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| Full name | | deleted in colorectal carcinoma |
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| Aliases | | ,CRC18,CRCR1,IGDCC1, |
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| Gene summary | | This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq] |
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| Location | | Chromosome: 18 Locus: 18q21.3 |
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| Gene position | | 49866542 - 51062273 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 1195732 bp |
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| Gene sequence |
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| OMIM ID | | 120470 |
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