Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DENND1B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID163486
Official gene symbolDENND1B
Full nameDENN/MADD domain containing 1B
Aliases,C1ORF18,C1orf218,DKFZp547O0715,FAM31B,FLJ20054,FLJ21179,FLJ33888,MGC103810,MGC27044,
Gene summaryClathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM]
LocationChromosome: 1   Locus: 1q31.3
Gene position197744623 - 197521385  Map Viewer
Gene orientationminus
Gene size223239 bp
Gene sequence
OMIM ID613292