Entrez gene ID | | 1645 |
Official gene symbol | | AKR1C1 |
Full name | | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) |
Aliases | | ,2-ALPHA-HSD,20-ALPHA-HSD,C9,DD1,DDH,DDH1,H-37,HAKRC,MBAB,MGC8954, |
Gene summary | | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10p15-p14 |
Gene position | | 5005454 - 5020158 Map Viewer |
Gene orientation | | plus |
Gene size | | 14705 bp |
Gene sequence |
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OMIM ID | | 600449 |
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