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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DDIT3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1649 Official gene symbol DDIT3 Full name DNA-damage-inducible transcript 3 Aliases ,CEBPZ,CHOP,CHOP-10,CHOP10,GADD153,MGC4154, Gene summary This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq] Location Chromosome: 12   Locus: 12q13.1-q13.2 Gene position 57914300 - 57910371  Map Viewer Gene orientation minus Gene size 3930 bp Gene sequence >DDIT3:complement(20053677..20057606):Length=3930 GAGGTCAGAGACTTAAGTCTAAGGCACTGAGCGTATCATGTTAAAGATGAGCGGGTGGCA GCGACAGAGCCAAAATCAGAGCTGGAACCTGAGGAGAGAGGCGAGTACTGATTCCCATCT ACCTTTTACCCTCCCGTCTCCTCAAAGTTGGGGCGTCCGCTCTTTAGGATCGGCCTCACT CCTCCACAGTGAAGTTAGGGACCGTCCGAGAGAGGAATGGGGAGAGTCCCTTATTCTGGG GTGGTGCTTACAAACCCCTATTGCTTCGGACGACGGCGTCTCTCCACCCCTGCCCGGAGC CGGAACACGGGCCCTGCTCTGTGCTGCTGGGCAAAGGGACCTCGGTTGCCCTTGGGAAAT TCATTCTTTCCCGTAGCCAACTTCAGGCCTCATCGTTAGGCCTGTCCGCGGGGAGGCAGG TCAGCAGGACACACCCCCGCTCTAAGACTGGGTGACCATCGCTCAGGCCGTTTCCGCCGC TTCGCCACCAGCGGGCCTTCTCCCTACCCCACCCCCAATTCTGTCTCAGTCTCAGTGCCT CTGGTGTCAGCATGGCCACCTTGGTAGCTGGGGCTACTGGACCCTGCAGCGGATAGGGGA ACCTTGAGGAGACACAAGCCTTTGGGAGGGGTGCCGATGGACAGGGAGTGGTGTGTTTTC CTTTTGCCGTAGAGGTCTCTGGGCCTCCTGCACAAGAGAGCAGCCTGGATCTCTTAAGTG TAGGAGGCCATTTGGGGTCTCCCCAGGGTATTGTCCTTCCCTCGGGATTAGTCCCTGCCT CTTTAACCCGGTCCTGTCTCCCAGCTAATCTCTGTGTAACCATTGCATCAGGCCAGCCCC GTTTGGCTCTGCAGCCTTCTGACCTGAGGCTCTACTGCTGATGAAAGCCAAGTCCCACAC ACTGGAAGGCAAGGGAGGGTTCCCCAGGGAGGACAGCCCTGCAGAGAAATACTTCGGGCA ATATTGCATCTCTAGCCCCTAGGGATCAGCAGCTGCCACTCTGCTTCTGCCCCTTCCCTA TAAGAGAGACTGGGGGGAGTTTATCCATTCATTCTTAACAAATACTTAATGAGGACCTAC TGTGTGCCACACAGTTTGGGGCTCAGGGTACATCCTTGAGCAAGAGGAAAAAATCATCTC AGTGGGAGGCCTACAGTAAACAAAATATAAGTGCCACGGAGAAAGCTAAAGCAGAGAAAG GAATGGAGAATGTTCAGGATGGAGGTCAGAGTGTTACATCAGGTGGTCAGGAATTACCTT AGGTAATTCCTCCACTCAAAACCCTTCAGTGACTTCCATGACATGAAATAGGAAGTCATT GGAGGGTTTGAGCAGAGGAATGACCTGTTTTAAAAGGCTCACTCAGGCTGCTGTATGGTG AATAGAGTTGCGGAGGGGTGGCAAGAGAAGAAATGGGAAGACCTTCTGCAGTCAGAAAGT TTCTGCAGTAATTTAGAGATGGTAGTGAATTGATCTAGATTGGAAACAATGGAATTAGAA GTGTTTAGATTCTTCTAAGCAAAGGTTTTAAAAACTCATTTTTAAAGAATGAGTTAAGGG CCGGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGACCAGAGGTGGGTGGAT CACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAATCCCATCTTTACTA AAAATACAAAAATTAGCCGGGCATGGCAGTGCATGCCTGTAATCCCAGCTACTCCGGAGG CTGAAGCAGGAGAATCGCTTGAACCCAGCAGGCGGAGGTTGCAGTGAGCCGATTGCGCCA CTGCCTTCCAGCCTGGGCAAAAAGAGTGAGACCCGTCTCAGAAAAAAAGGAATGAGTTAA AATTTGCTAGTACTTTGGATTGCAGGGTGTGAGAGAAGAGGAATGAAGGATGATACCAAG GTTTTTAGCTTAAGCAACTAGAGTTGTCATCTGAGATGGGGATGACCTTGGAAGGGGAAA ATCAGCAAGAGTTTGCCTTTGCACATAGTCTTAGGTGCCTATTAGACATTGAAAAAGAAA TGGCAAGTAGGCAGTAGACAGCAGAGTCTGAAGTTCTGGAAGAGGTCCAGACTGGAAATG TACATTTGGAGGATGTCAGCCCTGTGGGAATGGAGTTAGGAAAATGCTATGATTTGTTCC CTTCCCTGTAGTTTAGTTTTTACCCTGGCAGATTTGAGGCCTGCTTTGGATTTAGAGAAA GCTGAGTTGGCCAGGACTTTACTATTATGTAACCAGGACTACAAATGTCAGCAACTAAAA ATAAAGAAAGTCAGGCCCTCTTCTGCCCTTCGAAATGGCTACAGGGACCAAGTATGCATA CCCCACAAGACCAGAAGTAAGGAAGGACCAGTAGGAGGCTGGAGGTAAAAGAAAAATAAG GGCCCAGCACGGTAGCTCATGCCTATAATCCCAGCACTTTGGGAAGCGATGGATCACAAG GTTAAGAGATGGAGACCATCCTGGCCAACATAGTGAAACCCTATCTCTGCTAAAAACACA AAAATTAGCTGGGCGTGGTGGCACGCGCCTGTAGTCCCAGCTACTCGGGAGGCCGAGGCA GAAGAATCACTTGAACCGAGGAGGCAGAGGTTGCAGTGAGCCGAGATCGCACCACTGCAC TTCAGCCTGGCAACAGAGCAAGACTTGGTCTCAAAAAAAAAAAAAGAAAGAAAAAAAGAA AAAGAAAAGTAAGTTGCCTCTCCCCCTTCCAAAAATGGCTGACATTTCTCTTTGTTGCCC ACAGTGTTCAAGAAGGAAGTGTATCTTCATACATCACCACACCTGAAAGCAGGTAAACTT AACCTACCCTTTTCCAAAAATTTTAAACGGCAGGACAGTAAATATTTTAGATGTTAAAAG TCCTATAGTCTCTAGCGTGACTCTTCATCTCTGCCACTGTAGCACCAAAGCAGCCATAAA CAATATGTAAATAAACAGATGTGGCTGTATTCCAGTACAACTTTACCTACAAAAACAGGC ATCAGACCAGCTTGCCAACTTGTGGCATAGACTGTTTGCTACATGGAGCTTGTTCCAGCC ACTCCCCATTATCCTGCAGATGTGCTTTTCCAGACTGATCCAACTGCAGAGATGGCAGCT GAGTCATTGCCTTTCTCCTTCGGGACACTGTCCAGCTGGGAGCTGGAAGCCTGGTATGAG GACCTGCAAGAGGTCCTGTCTTCAGATGAAAATGGGGGTACCTATGTTTCACCTCCTGGA AATGAAGAGGTAAGAATGTTAGCCCTAAAGCTAAAGGGGGATGTTACCTTTCCCTTCTCA ACTAATATCTATGTTCCCTTTCCTCATTTCCTTGAAGGAAGAATCAAAAATCTTCACCAC TCTTGACCCTGCTTCTCTGGCTTGGCTGACTGAGGAGGAGCCAGAACCAGCAGAGGTCAC AAGCACCTCCCAGAGCCCTCACTCTCCAGATTCCAGTCAGAGCTCCCTGGCTCAGGAGGA AGAGGAGGAAGACCAAGGGAGAACCAGGAAACGGAAACAGAGTGGTCATTCCCCAGCCCG GGCTGGAAAGCAGCGCATGAAGGAGAAAGAACAGGAGAATGAAAGGAAAGTGGCACAGCT AGCTGAAGAGAATGAACGGCTCAAGCAGGAAATCGAGCGCCTGACCAGGGAAGTAGAGGC GACTCGCCGAGCTCTGATTGACCGAATGGTGAATCTGCACCAAGCATGAACAATTGGGAG CATCAGTCCCCCACTTGGGCCACACTACCCACCTTTCCCAGAAGTGGCTACTGACTACCC TCTCACTAGTGCCAATGATGTGACCCTCAATCCCACATACGCAGGGGGAAGGCTTGGAGT AGACAAAAGGAAAGGTCTCAGCTTGTATATAGAGATTGTACATTTATTTATTACTGTCCC TATCTATTAAAGTGACTTTCTATGAGCCAA OMIM ID 126337