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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DEFA3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1668 Official gene symbol DEFA3 Full name defensin, alpha 3, neutrophil-specific Aliases ,DEF3,HNP-3,HNP3,HP-3,HP3, Gene summary Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq] Location Chromosome: 8   Locus: 8pter-p23.3 Gene position 6875816 - 6873391  Map Viewer Gene orientation minus Gene size 2426 bp Gene sequence >DEFA3:complement(6863391..6865816):Length=2426 CCTTGCTATAGAAGACCTGGGACAGAGGACTGCTGTCTGCCCTCTCTGGTCACCCTGCCT AGCTAGAGGATCTGTAAGTACTACAAAACTTAAACTTTACACTGAGTTTTCATCATTGAA GCTATGCCTCCAATCTGACCTCTGACTGTGGGGCCGCCCCAGAGGGACCCAGCGGGTGAA TCCCTGCTAGGAACGTCTGTCCGGACCTCTGGTGACTGCTGGGGACGATGGCTTCCAGCT AACTTAATAGAGAAACTCAAGCAGTTTCCTTCTAAACACACATGTCCTGGTTGACATGTC CAGTAGAGACTATCACAGGTCTTTGGAACATTCTTTTGAGAGAAACCTATTTAGGTCCTT GGTCTGTCTTTCAATCAGGTTGTTTGATTTTTGCTATTGAGTTGTTGGAATTCCTTATGT ATTCAGATATTTGCCCCTTCTGCCATGTAGGTTTTGCAAATATTTTCTCTCATTTTCTGG GTTATCTTTTCACTCGGTTGATTGTTTCCTTTGCTGTGCAGATGCTTTAGCGTTAAATGA AGCCACACTTGTCTATTTTCCCTTTTATTGCCTGTGCCTTTGGTGTCATAGCCAAGAAAT CATTACCTACATCAATGTCAAAAGCTTTATCCTTCTATACACTTCTAGTAGTTTATGGTT TCAGTTGTTACATTTAGGTTTTCAATTCATTCTGAGTTGATGTTTCTACATGGTGTGAGA TAAAGATTTAAATACATACATATATAAAATCATGAGGTAGTGTACACTATAAATATACAA TTGTTAATTGTTACTCAAGTCTAAGTAGAGGTGGAAATAATAAACTTTCTTTTTTTTACT TAAACCACTCTGTGTCACTGAGCTGATTTCACCTTTAGCCTGATAAAATCATTGTCCTCT CCACCCTGATTCCTACAGGAGACTACTCACCCCATAACCTCAAAAACCTCTTCATGAGGA TGGTAAGTCACCTGAATCCTGAAGTGAATTACTCGCTATTCCATTGGAACTCATATAGGA CACCAGAATCTAGACCTCCAGAGAACAGCAGGACCCATCTTCAGAAAATAAGAAGCATTT GTTCCCTGAGCCTGTTGAATCAAAGTGCAATTTCTATTCTTTTTGGAATGTTAAAAAGTA AATCATAATATTTAAGCAGGTGAACCCACGAGTAACATAGCAGGGTCTTTCTTGTCATTA TTAGCTCCAACCTAGCACAGACATTAAAGGTACAGATGTATACTAGCATGAAACTGGGAG AACAGGAGCATTCGAGCAACCTTGAGACCAATGGGCCTCTCTTGTAAAATGCACACCTCC TCTCACTGAGATTGAGGAAGGTTTCTTGTCTCCGAGCCTTCTCCCAGTAGAGCTATAAAT CCAGGCTGGCTCCTCCCTCCCCACACAGCTGCTCCTGCTCTCCCTCCTCCAGGTGACCCC AGCCATGAGGACCCTCGCCATCCTTGCTGCCATTCTCCTGGTGGCCCTGCAGGCCCAGGC TGAGCCACTCCAGGCAAGAGCTGATGAGGTTGCTGCAGCCCCGGAGCAGATTGCAGCGGA CATCCCAGAAGTGGTTGTTTCCCTTGCATGGGACGAAAGCTTGGCTCCAAAGCATCCAGG TGAGAGAGGCAGGCATGCAGAGCTGCTAAGTCTAGAGGGAAGGACGGGAGAGAGGTTCCA GAGTTGGGTCTCAGCAGTCTATGTCACTGAGGTGGCTTCACTTAGAATCTCTGGGCATTG ATTTTCTCATCTAGAAATTGAACAGAGAGCCAAATAAACCTGAGAAACTTTATTTCTCCA AAGACTTGATTCCAAGAAACATCTGTGAAATTCACTAAGTTTAAGATATGAAGAGACAGA CTAGTTATTTCTGGATCTAAACAAGTAGACTTAGTTGTAAAGAGAACATTTTACTCTACA GAAGAGCTTTTAAAAACTGCAGCCAAGCCTGAGGGTATGTTCAGGTGTGTGTGTGATGGG GCAGGAATGCAAAAATGAGAGCAAAGGAGAATGAGTCTCAAATTCTGTGTGACAAGCACT GCTCTGCGTGTTTATTCCTATCGACTGAGGTTGTTCGTGCTAACGGCTGCAATGCAGCCA GCATCACCTGTCAGCTAGCATGTGACTTCCCCGAGATTCTTTTTCTTACCCACTGCTAAC TCCATACTCAATTTCTCATGCTCTCCCTGTCCCAGGCTCAAGGAAAAACATGGACTGCTA TTGCAGAATACCAGCGTGCATTGCAGGAGAACGTCGCTATGGAACCTGCATCTACCAGGG AAGACTCTGGGCATTCTGCTGCTGAGCTTGCAGAAAAAGAAAAATGAGCTCAAAATTTGC TTTGAGAGCTACAGGGAATTGCTATTACTCCTGTACCTTCTGCTCAATTTCCTTTCCTCA TCTCAAATAAATGCCTTGTTACAAGA OMIM ID 604522