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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DEFA4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1669 Official gene symbol DEFA4 Full name defensin, alpha 4, corticostatin Aliases ,DEF4,HNP-4,HP-4,HP4,MGC120099,MGC138296, Gene summary Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq] Location Chromosome: 8   Locus: 8p23 Gene position 6795786 - 6793345  Map Viewer Gene orientation minus Gene size 2442 bp Gene sequence >DEFA4:complement(6783345..6785786):Length=2442 GTCTGCCCTCTCTGCTCGCCCTGCCTAGCTTGAGGATCTGTAAGTAACACAAAACTTAAA CTTTCACATTGAGGTTTCAATATTGAAGCTGTGTCCCCAGTCTGACCTCTCACTGTGGGG CCACCCCAGAGGGACCCAGCGGGTGAAGCCCCTGCTGTGAACTTCTATCTGGGTGTCTGG CGGCTGCTGGGGGTAATGGCTACTAGCTAAGTCAATAGAGAAACTCAAAAAGTTTCCTTC CAAACACACGTGTCCTACTTGACATGTCCAATAAAGACGATCACAGCTTCTTAAAACATT ATTTTATTGTGAGAGAAGCCTCTGCAGGTCCTAGGTCTGTTTTTCAATCAGGTTGTTTGT TTTTTGCTATTGAGTTGTTTGACTTCCTTATGTATTCAGATATTTACCCCTTCTACCACG TAGGCTTTGCAAACATTTTCTCTCATTTTCTGGGTTGCCGTTTCCCTCAGTTGATTGTTT CCTTTGCTATGAAGATGCTTTAGCGTTCAATGCAGCCCCGCTTGTCTATTTTCCCATTTG TTTATTGCCTGTGCCTTTGGTGTCATAGCCAAGAAATCATTACTCACGTCAATGTCCAAA GCTTTATCTTTGTATGTGCTTCTCGTAGTTGTATGGTTTCAGGTCTTTTCAAGTCTATGT TGAGTCTTCAATCCATGTTGAGCTGATTTTTTACATGCTGTGAGAGAAAGGACCACGTGT ATGCACCTAGCAACTCATGAACCTTACACAACTCTTTATCTCTCTCACTGAGCTCATTTC ACCTGTACCCTGATAAGGTCATTGTCCTCTTCACTCTGGCCCCTACAGGAGACTACTCAC CCCATTACCTCAGTCGCCCCTTCATGAGGGTATAATGACCTAGAAGCCTGCAATGAGTTA CTCTCTACTCCACCGGAATACAGGTCTGGCACCAGTGTTTAGACCTGAAGAGAATAGTAG GGCCCATTATCAGGAAATAAGAGGCATTTGCTCTCTTAAATTATTGAATGAAAGCACTGT TTCCATTCTTTTTAGAATATTAAAGATTTAACCAGGAAATATTAGGTATTTCCTGAAAAC AGGAAAAAATGCCAGGGTCCTCATCATCACCATCAACTTCAACCTAGCACAGACACTAAA CATAGAGCTTCCTGTGAAGAAAGCTGGGAGAGCAGAGGAGCATTCCAGGGATGTCAAGGC CAATAGGAGTCGGCATCCTCTCTAACAAAATGCACACCTCCTCTCACTCAGAAGGCCAAA GGTTTCTTATCTCTGTGCCTTCTCCCAGCAAAGCTATAAATCCAAGCTGGCTTCTCCCTC CCCACACAGCTGCTCCTGCTCTCCCTCCTCCAGGTCACCCCAGCCATGAGGATTATCGCC CTCCTCGCTGCTATTCTCTTGGTAGCCCTCCAGGTCCGGGCAGGCCCACTCCAGGCAAGA GGTGATGAGGCTCCAGGCCAGGAGCAGCGTGGGCCAGAAGACCAGGACATATCTATTTCC TTTGCATGGGATAAAAGCTCTGCTCTTCAGGTTTCAGGTGAGAGAGGCCAGCATAAAAAA GCTACCGAGTCTAGAGAGACGGATGGGAGATGGGCTCTGGAATCACATCTCAATGGTGGA TGTCACTTAGGTGGCTTTACTTACCATCTCTGGGCCTCGATTTTCTTATCTCCAAACTGA ATAGAGAGACAAACAAATGTAAGTAGTCTTCTTTCTCCAAAGACTTGATTCCAAGGTATG TCTATAAAATTCGCTAGGGTTAAGATACGGAGAGACAGATTGACCAGTTCTTTCTGGATC TAAACAAGTAGATATTATAGGGAAAATATTTCATTCTGCCAACAAAGGAAATTTTAAAAA CTGGAGATGGGCTTAAGAGTATGTTCAGGTGTGTGTCTGATGGGGCAAAAGCACACAAAT CAGAGCAAAAGAGAATGAGTCTCAAATCCTGTATGAGCAGCATTGCTCTGTGTATTTATT CCTATTGACTAAGGTTGTTTGTGCTACCGGCACTAATGCAGCCAGCATCACCGGTCAGCC AGCATGTGACTTCTCCAAGATTCCCTTTACCACCCACCGCTGACCTTGGTGCTTAATTTC TCATGCTTCCTCTGTGTTCCCAGGCTCAACAAGGGGCATGGTCTGCTCTTGCAGATTAGT ATTCTGCCGGCGAACAGAACTTCGTGTTGGGAACTGCCTCATTGGTGGTGTGAGTTTCAC ATACTGCTGCACGCGTGTCGATTAACGTTCTGCTGTCCAAGAGAATGTCATGCTGGGAAC GCCATCATCGGTGGTGTTAGCTTCACATGCTTCTGCAGCTGAGCTTGCAGAATAGAGAAA AATGAGCTCATAATTTGCTTTGAGAGCTACAGGAAATGGTTGTTTCTCCTATACTTTGTC CTTAACATCTTTCTTGATCCTAAATATATATCTCGTAACAAG OMIM ID 601157