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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NLRP6 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 171389 Official gene symbol NLRP6 Full name NLR family, pyrin domain containing 6 Aliases ,CLR11.4,NALP6,PAN3,PYPAF5, Gene summary NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM] Location Chromosome: 11   Locus: 11p15 Gene position 278570 - 285304  Map Viewer Gene orientation plus Gene size 6735 bp Gene sequence >NLRP6:218570..225304:Length=6735 ATGGACCAGCCAGAGGCCCCCTGCTCCAGGTGAGTGCTGGCCCCAGGGTGGTCACTGGGA ACCGGCTGGTCTCAGCCCTCTGGGGCCTCCACCTCACCCGCTGACTTCCTCAGGCTCTCC ACCCTTGTCCACATCCTTCCCCCACCCTCACTCCCAGGCTCAGGAGCCAAGCACTGCCTC CCCACAGAGGGCATTTGTGGAGTCTGTTCCCCACCAGGGGCTCAGATTCAGGCCCTGGTG CAAGGCCCCAAGCTGGGCCCCACCAAAGTGTGGCAGGGGTGGGGGCCCAGGAATACAGCC TGGGCCTGGCAGTGTCTGCTGCCAAAGAGGCCAGTTCTGCTCCGGGATCGGGAAGAGAGG GAAAAGAAGGAAAGCGAGGAAAGAGAGCTCAGGGTTCCTTGGAAATACCTCCCTCGGGGC ATGTGACCTGTCCTGGGGTGTGGAAGGACAGAAGCAGAAAGGGAGGTGCAGGGGAGGAAG GTGCCCCCCAGAGCTCAGATCAGCGGCGGCCAGTGCCCACTTCACCCTCAGAGGGCGAAG AACACCAAGACGCCCCGACCCGGGTCCGGGGACGGGGGAGGGAAAAGTCTGGGGTCACTC CCCGTTGCCCCCTCCCGCCACCCCATGGATCCAGACGATGCTTGGCCCGGGACTCCCTGA GGCCCTGCCCGCGGTGGGTTCTCCGGCGCCAGAGTCGGGGGCGGGCGGGGGTCACCCGAG GGCCGCTCCCCGATGACCCGCGCCCGCCCGCCTCCAGCACGGGGCCGCGCCTCGCGGTGG CCCGCGAGCTGCTCCTGGCTGCGCTGGAGGAACTGAGCCAAGAGCAGCTGAAGCGCTTCC GCCACAAGCTGCGCGACGTGGGCCCGGACGGACGCAGCATCCCGTGGGGGCGGCTGGAGC GCGCGGACGCCGTGGACCTCGCGGAGCAGCTGGCCCAGTTCTACGGCCCGGAGCCTGCCC TGGAGGTGGCCCGCAAGACCCTCAAGAGGGCGGACGCGCGCGACGTGGCGGCGCAGCTCC AGGAGCGGCGGCTGCAGCGTGAGTTCTGCGCGGGAGGTCCCTCCTGTCTGGGCAGAGGCT GGGCTGCCCTCCTTCCCGCTTCCCGGAGAAGCCCCGGCGCGGTCCCCGGCCCCCGCGCGT TTTATCCACAAATTCGCGGGCCCCAGGGGTAGGACCCTGCGTGCTCCTCAGGGTGACTCG GACCCCCGTGGCGCCTTCCCCTGTTCCCGCCCTCGGCGGAACCTCACCCCAGTTTCCCTT CCAGGGCTCGGGCTCGGCTCCGGGACGCTGCTCTCCGTGTCCGGTGGGTCTCTCGCTGGG GGGGCACGAGTGTCCCCAACCCCACTTGGAGGGTCCCGGGGAGGACCGGGGTGGGAGGGC CGCCAGGGGCGTGGGCTGTGGTCCCGTAGAGGAAACTGAGGCCTGAGCAGGGCCGGGGAG GGCGTGGGCTCCCGGAGGGCGCAGCCTGCCCCACCTCCGACCCTTGTCCCCGCGCTGTCT CCCGCTGCGCCCAGAGTACAAGAAGAAGTACCGGGAGCACGTGCTGCAGCTGCACGCTCG GGTGAAGGAGAGGAACGCCCGCTCCGTGAAGATCACCAAGCGCTTCACCAAGCTGCTCAT CGCGCCCGAGAGCGCCGCCCCGGAGGAGGCGATGGGGCCCGCGGAAGAGCCTGAGCCGGG GCGCGCGCGGCGCTCGGACACGCACACTTTCAACCGCCTCTTCCGCCGCGACGAGGAGGG CCGGCGGCCGCTGACCGTGGTGCTGCAGGGCCCGGCGGGCATCGGCAAGACCATGGCGGC CAAAAAGATCCTGTACGACTGGGCGGCGGGCAAGCTGTACCAGGGCCAGGTGGACTTCGC CTTCTTCATGCCCTGCGGCGAGCTGCTGGAGAGGCCGGGCACGCGCAGCCTGGCTGACCT GATCCTGGACCAGTGCCCCGACCGCGGCGCGCCGGTGCCGCAGATGCTGGCCCAGCCGCA GCGGCTGCTCTTCATCCTGGACGGCGCGGACGAGCTGCCGGCGCTGGGGGGCCCCGAGGC CGCGCCCTGCACAGACCCCTTCGAGGCGGCGAGCGGCGCGCGGGTGCTAGGCGGGCTGCT GAGCAAGGCGCTGCTGCCCACGGCCCTCCTGCTGGTGACCACGCGCGCCGCCGCCCCCGG GAGGCTGCAGGGCCGCCTGTGTTCCCCGCAGTGCGCCGAGGTGCGCGGCTTCTCCGACAA GGACAAGAAGAAGTATTTCTACAAGTATTTCCGGGATGAGAGGAGGGCCGAGCGCGCCTA CCGCTTCGTGAAGGAGAACGAGACGCTGTTCGCGCTGTGCTTCGTGCCCTTCGTGTGCTG GATCGTGTGCACCGTGCTGCGCCAGCAGCTGGAGCTCGGTCGGGACCTGTCGCGCACGTC CAAGACCACCACGTCAGTGTACCTGCTTTTCATCACCAGCGTTCTGAGCTCGGCTCCGGT AGCCGACGGGCCCCGGTTGCAGGGCGACCTGCGCAATCTGTGCCGCCTGGCCCGCGAGGG CGTCCTCGGACGCAGGGCGCAGTTTGCCGAGAAGGAACTGGAGCAACTGGAGCTTCGTGG CTCCAAAGTGCAGACGCTGTTTCTCAGCAAAAAGGAGCTGCCGGGCGTGCTGGAGACAGA GGTCACCTACCAGTTCATCGACCAGAGCTTCCAGGAGTTCCTCGCGGCACTGTCCTACCT GCTGGAGGACGGCGGGGTGCCCAGGACCGCGGCTGGCGGCGTTGGGACACTCCTGCGTGG GGACGCCCAGCCGCACAGCCACTTGGTGCTCACCACGCGCTTCCTCTTCGGACTGCTGAG CGCGGAGCGGATGCGCGACATCGAGCGCCACTTCGGCTGCATGGTTTCAGAGCGTGTGAA GCAGGAGGCCCTGCGGTGGGTGCAGGGACAGGGACAGGGCTGCCCCGGAGTGGCACCAGA GGTGACCGAGGGGGCCAAAGGGCTCGAGGACACCGAAGAGCCAGAGGAGGAGGAGGAGGG AGAGGAGCCCAACTACCCACTGGAGTTGCTGTACTGCCTGTACGAGACGCAGGAGGACGC GTTTGTGCGCCAAGCCCTGTGCCGGTTCCCGGAGCTGGCGCTGCAGCGAGTGCGCTTCTG CCGCATGGACGTGGCTGTTCTGAGCTACTGCGTGAGGTGCTGCCCTGCTGGACAGGCACT GCGGCTGATCAGCTGCAGATTGGTTGCTGCGCAGGAGAAGAAGAAGAAGAGCCTGGGGAA GCGGCTCCAGGCCAGCCTGGGTGGCGGCAGGTGCGTCTCCAGGGCAGAGATACTCTCTTG TGTGTGAGGTGTGTGTGCCGGTGCAAACCTGTGCACCTCAGTGTCCATCTGGCATGGGGC GCACCTCCAGACCAGACCCTGGCTCCCCAGATGGGGAGGCTTTGACCACCTCCTTGCAAG GCAACCACTGAATTCCTATCTTCTTCCCCAGGGTGTCCTCACCATGCCCACCGTCAGCCA CCCACAACCTATGAAAACTTCCTAGTATGGCCCTACAGCTCTGGCCCAGCCCTTCTTCCC ATTTTACTTTCTGACAATAAGCTCTGGAACACACGATGCCCTCTGTCCAGAGCCTCTGCA CTTGCCCTTCCCTCCACCTAGAATATTCTGTTTGCTGCCTGTCCTGCAAGTCTGCCCTGG CTCCCCCAGCTGGCTGGGGACCCAACTGGCTCCAGAAGTACCCTTTCGACCACCCTGCTG TGACATCTGCCCCACACCTCCACCAGACCCTCGGCTCCTCCAGGGCAAGGCTTTTGCCAG AGTTCCTTTGAATATAGCTCCAATTCAGCCCCTGCCCAGGGGCTTGGCATCTGTTGAGAG GATGAATGTCACGGTGTTGGCAGGGGCTGGGCCTGGGGACCCAAAGACCCATGTAGAGGA TGTGGGTGATACCGTCCCACTGACCTCACTCAGACACCCCAGTGGGATGATGCCTGGGCC ACAGATGAGTGGTTTTGCTCTGGGTTTGGTTGGGGGAGTGTGAAGGGGGTGGCTCAGCAA GGAGGTGAGGAGGAGGGGCAGCTCTGAGACCCCAGGACTACAGATAGACAGGAGTCCTTT CCGGCAGGCACTGTGAGGAGCAGGGTGGGCTTCACCTTCCTCTCTCTCCCAGCAGTTCTC AAGGCACCACAAAACAACTGCCAGCCTCCCTTCTTCATCCACTCTTTCAGGCAATGACTG ACCCACTGTGCCATCTGAGCAGCCTCACGTGAGTGGCCACACCCCCAGCTCTTCCCACGG AGCGGGCTGAGAGCAGGATGCCCTGGGCAGAGACGGAAGTATGACCTAGGAAAGAAGGCT GAGGGGTCAGACCAGAGCCTGAGGCCTGTGGGTGCTGGAGATGGCAGGCTCTGCCCACAC AGAGCAGAGGGAGGAGGGGATGAGGGTCTGGGGCTTCATTACCAGGTTAGGTACTGGTAG GAAAAGGTTGGTCCTGGTGAGTGGAAAGCAGCTAAGCACACTGAGGGAGGGATTAAAGAA GACAAGAGTGTATTTTCCTTCTGAAGGGAGGCTGCCGTTGGAAACTGCTGGGTTCTCAGA AGCAGTGGAGGAAGGTGTTCAAGCGCAGGCTCCAAGGTCAGGCTGTCTGCAAATGCTAGC CGGCTTCTGCGTGCCCAGTAGCAAGTCCATCTGTCCGAGCTTCCATTTCCTCCCCTGTGA AATGGAGCCAGTAGATCCAGAGAGTTGGGGTGAGATTTAATGTGGCTACACATGTACAGT TCTTTTTTTTTTTTTTTTTTTTGAGACGGAGCCTCGCTCTGTCGCCCAGGCTGGAGTGCA GTGGTGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCT CAGCCTACTGAGTAGCTGGGACTACAGGTGCCCGCCACTACGCCCGGCTAATTGTTTGTA TTTTTAGTAGAGACAGGGTTTCACCGGGTTAGCCAGGATAGTCTCGATCTCCTGACCTCG TGATCCACCCGCCTCTGCCTCCCAAAGTGCTGGGATCACAGGCATGAGCCACCGCGCCCG GCCACATGTACAGTTCTTACATGGCAATAACTTGCCAGTCACTCTTAGCTACCACCAAGT GAGCAGAAAGGAAGAGGAAATCTAGGAACTAGTACTGATGGTGAAACAGGTCCATCCTAC GTTGATGGCAACTCGGCAAATTAGCTTGATATGGGGGTGGGGGATTTGGCAATCTGGAGA TAAACATAAGAACCAAAAAGGTGATCACATTTGGCCCAGCAATTCTGCTGGTAAAGTAAG ATGTTCAGCACACCATTATTTATAATGGAAAAAAAAAAAAGGAGAAACAACACAACTACC CAACCATTAGGGAATAGCGGACTAAATAAACTGAGTTGGCCACCTCATCTTGGTGGACGA TTGTGCGGCAAACATGTTGAAACACGTCTCAGCTCTCCGAAGAGCTCGTAGAGAGTGTCG CAGGGAGAAATGAACACAGCTCCCCGGGGGTGCATGGTGACAAAGGGCAGGGCAGGCTCT GCGAGGTCCAGGGAAGGATGTGGCACCAACACATCTCTCAGCTGAACCCTGGGCCACCGG GCAGCGGGCATTTTGTGCAGTTGGAGGTGGTGTGGTGGCTGAGGCGCCTGCAGGTAAATC TCTGTGCTTCTTGACCACAGGCTGTCCCACTGCAAACTCCCTGACGCGGTCTGCCGAGAC CTTTCTGAGGCCCTGAGGGCAGCCCCCGCACTGACGGAGCTGGGCCTCCTCCACAACAGG CTCAGTGAGGCGGGACTGCGTATGCTGAGTGAGGGCCTAGCCTGGCCGCAGTGCAGGGTG CAGACGGTCAGGTGAGGCCTGGCCTGGGAGGGACCGTGGGATGCCCCCGCCACCCCAGCA GCTCCTGAGGTCGGCCCTCCCACAGGGTACAGCTGCCTGACCCCCAGCGAGGGCTCCAGT ACCTGGTGGGTATGCTTCGGCAGAGCCCTGCCCTGACCACCCTGGATCTCAGCGGCTGCC AACTGCCCGCCCCCATGGTGACCTACCTGTGTGCAGTCCTGCAGCACCAGGGATGCGGCC TGCAGACCCTCAGGTGGAGGCAGGGGTGGGAAGGGTGCTGGGGACACAGCCTGTCAACCC GGGGAGGGGGAGGGTGCCTGGGGGCTCCCCCTGGACCCTGAAGAGGGGCCCCTCCCAGAG ACCTCCCATGTGACTGAGCTCAAACACTGACCTGGGAGCCCAGCCCTGACAGCCCTGCCC TCTGAAGCCCTGGCCACAGCTCGGGGCCTTGACCACTTTGTCTGACCAAATGTTCATCTG TTGTCTGGTGCCCATGGCAGCACCCTGGGCCAGTGGCCCCGATACCCTTTTGCCACCCCC AAGGTCCGGCCTCTGCCCCCTCCCCCAGCCTCTGACAAACCTCTCAACTGACACCACCTG TCCCTGAGTGTCTGTGGCACAGCCAAGCTGACAGCCCAGTCACTGCCCGCAGCCCGGCCA CCCCCACGGCACTGCCCGTCACTGCCCGCGGCCCGGCTGCCCCCACGGCACTGCCCCCAA GCCCTGGCTGCTTTCCCCCACCGCTGACCCCGCTTCTGCTCTGCGTGTGGCTGCAGTCTG GCCTCTGTGGAGCTGAGCGAGCAGTCACTACAGGAGCTTCAGGCTGTGAAGAGAGCAAAG CCGGATCTGGTCATCACACACCCAGCGCTGGACGGCCACCCACAACCTCCCAAGGAACTC ATCTCGACCTTCTGA OMIM ID 609650