Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CYB5R3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1727
Official gene symbolCYB5R3
Full namecytochrome b5 reductase 3
Aliases,B5R,DIA1,
Gene summaryThis gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q13.31-qter|22q13.
Gene position43045405 - 43013846  Map Viewer
Gene orientationminus
Gene size31560 bp
Gene sequence
OMIM ID613213