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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for AFP (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID174
Official gene symbolAFP
Full namealpha-fetoprotein
Aliases,FETA,HPAFP,
Gene summaryThis gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q11-q13
Gene position74301933 - 74321492  Map Viewer
Gene orientationplus
Gene size19560 bp
Gene sequence
OMIM ID104150