Entrez gene ID | | 17540 |
Official gene symbol | | Mrvi1 |
Full name | | MRV integration site 1 |
Aliases | | BB115629,Irag,Ris1 |
Gene summary | | This gene is a putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Studies in mouse suggest that MRV integration at this locus induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Additional isoforms may arise through the use of alternative non-AUG (CUG) translation initiation site. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7 F1|7 51.52 cM |
Gene position | | 118125609 - 118011781 Map Viewer |
Gene orientation | | minus |
Gene size | | 113829 bp |
Gene sequence |
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